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In vitro assays for...
In vitro assays for investigating the FLASH effect
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- Adrian, Gabriel (författare)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Ruan, Jia Ling (författare)
- University of Oxford
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- Paillas, Salomé (författare)
- University of Oxford
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- Cooper, Christian R. (författare)
- University of Leicester
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- Petersson, Kristoffer (författare)
- Lund University,Lunds universitet,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Oxford,Skåne University Hospital
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(creator_code:org_t)
- 2022-02-28
- 2022
- Engelska.
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Ingår i: Expert Reviews in Molecular Medicine. - : Cambridge University Press (CUP). - 1462-3994. ; 24
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.cambridg...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- FLASH radiotherapy is a novel technique that has been shown in numerous preclinical in vivo studies to have the potential to be the next important improvement in cancer treatment. However, the biological mechanisms responsible for the selective FLASH sparing effect of normal tissues are not yet known. An optimal translation of FLASH radiotherapy into the clinic would require a good understanding of the specific beam parameters that induces a FLASH effect, environmental conditions affecting the response, and the radiobiological mechanisms involved. Even though the FLASH effect has generally been considered as an in vivo effect, studies finding these answers would be difficult and ethically challenging to carry out solely in animals. Hence, suitable in vitro studies aimed towards finding these answers are needed. In this review, we describe and summarise several in vitro assays that have been used or could be used to finally elucidate the mechanisms behind the FLASH effect.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cell models
- cells
- dose rate
- radiation
- radiotherapy
- ultra-high
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- for (ämneskategori)
- ref (ämneskategori)
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