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Cumulative Absolute...
Cumulative Absolute Risk of Subsequent Colorectal Cancer After Abdominopelvic Radiotherapy Among Childhood Cancer Survivors : A PanCareSurFup Study
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- Heymer, Emma J. (författare)
- University of Birmingham
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Jóźwiak, Katarzyna (författare)
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- Kremer, Leontien C. (författare)
- Academic Medical Center of University of Amsterdam (AMC),Princess Maxima Center for Pediatric Oncology/Hematology
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- Winter, David L. (författare)
- University of Birmingham
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- de Vathaire, Florent (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Sunguc, Ceren (författare)
- University of Birmingham
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- Sugden, Elaine (författare)
- University of Birmingham
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- Kok, Judith L. (författare)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- van der Pal, Helena J.H. (författare)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Hjorth, Lars (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Jakab, Zsuzsanna (författare)
- Semmelweis University
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- Maule, Milena M. (författare)
- Karolinska Institutet
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- Haupt, Riccardo (författare)
- Gaslini Children's Hospital
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- Bagnasco, Francesca (författare)
- Gaslini Children's Hospital
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- Terenziani, Monica (författare)
- Istituto Nazionale dei Tumori
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- Diallo, Ibrahima (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Gunnes, Maria W. (författare)
- Norwegian Radium Hospital,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Sommer, Grit (författare)
- University of Bern
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- Zaletel, Lorna Zadravec (författare)
- Institute of Oncology, Ljubljana
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- Kuehni, Claudia E. (författare)
- University Children's Hospital Bern,University of Bern
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- Winther, Jeanette F. (författare)
- Danish Cancer Society,Aarhus University Hospital
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- Lähteenmäki, Päivi M. (författare)
- Turku University Hospital
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- Gudmundsdottir, Thorgerdur (författare)
- Danish Cancer Society,National University Hospital of Iceland
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- Allodji, Rodrigue S. (författare)
- Centre for Research in Epidemiology and Population Health (CESP)
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- Skinner, Roderick (författare)
- University of Newcastle upon Tyne
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- Ronckers, Cécile M. (författare)
- Carl von Ossietzky University of Oldenburg,Princess Maxima Center for Pediatric Oncology/Hematology
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- Hawkins, Michael M. (författare)
- University of Birmingham
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- Reulen, Raoul C. (författare)
- University of Birmingham
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- Teepen, Jop C. (författare)
- Princess Maxima Center for Pediatric Oncology/Hematology
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(creator_code:org_t)
- 2024
- 2024
- Engelska 12 s.
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Ingår i: Journal of Clinical Oncology. - 0732-183X. ; 42:3, s. 336-347
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
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- PURPOSE Childhood cancer survivors are at the risk of developing subsequent colorectal cancers (CRCs), but the absolute risks by treatment modality are uncertain. We quantified the absolute risks by radiotherapy treatment characteristics using clinically accessible data from a Pan-European wide case-control study nested within a large cohort of childhood cancer survivors: the PanCareSurFup Study. METHODS Odds ratios (ORs) from a case-control study comprising 143 CRC cases and 143 controls nested within a cohort of 69,460 survivors were calculated. These, together with standardized incidence ratios for CRC for this cohort and European general population CRC incidence rates and survivors' mortality rates, were used to estimate cumulative absolute risks (CARs) by attained age for different categories of radiation to the abdominopelvic area. RESULTS Overall, survivors treated with abdominopelvic radiotherapy treatment (ART) were three times more likely to develop a subsequent CRC than those who did not receive ART (OR, 3.1 [95% CI, 1.4 to 6.6]). For male survivors treated with ART, the CAR was 0.27% (95% CI, 0.17 to 0.59) by age 40 years, 1.08% (95% CI, 0.69 to 2.34) by age 50 years (0.27% expected in the general population), and 3.7% (95% CI, 2.36 to 7.80) by age 60 years (0.95% expected). For female survivors treated with ART, the CAR was 0.29% (95% CI, 0.18 to 0.62) by age 40 years, 1.03% (95% CI, 0.65 to 2.22) by age 50 years (0.27% expected), and 3.0% (95% CI, 1.91 to 6.37) by age 60 years (0.82% expected). CONCLUSION We demonstrated that by age 40 years survivors of childhood cancer treated with ART already have a similar risk of CRC as those age 50 years in the general population for whom population-based CRC screening begins in many countries. This information should be used in the development of survivorship guidelines for the risk stratification of survivors concerning CRC risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Heymer, Emma J.
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Jóźwiak, Katarzy ...
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Kremer, Leontien ...
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Winter, David L.
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de Vathaire, Flo ...
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Sunguc, Ceren
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visa fler...
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Sugden, Elaine
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Kok, Judith L.
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van der Pal, Hel ...
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Hjorth, Lars
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Jakab, Zsuzsanna
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Maule, Milena M.
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Haupt, Riccardo
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Bagnasco, France ...
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Terenziani, Moni ...
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Diallo, Ibrahima
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Gunnes, Maria W.
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Sommer, Grit
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Zaletel, Lorna Z ...
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Kuehni, Claudia ...
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Winther, Jeanett ...
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Lähteenmäki, Päi ...
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Gudmundsdottir, ...
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Allodji, Rodrigu ...
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Skinner, Roderic ...
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Ronckers, Cécile ...
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Hawkins, Michael ...
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Reulen, Raoul C.
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Teepen, Jop C.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Journal of Clini ...
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Journal of clini ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet