Sökning: onr:"swepub:oai:lup.lub.lu.se:8fa0e5c7-3d8e-4015-9900-3631b13a0ccb" > Cumulative Absolute...
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000 | 06806naa a2200709 4500 | |
001 | oai:lup.lub.lu.se:8fa0e5c7-3d8e-4015-9900-3631b13a0ccb | |
003 | SwePub | |
008 | 240219s2024 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:237972325 | |
009 | oai:prod.swepub.kib.ki.se:158410077 | |
024 | 7 | a https://lup.lub.lu.se/record/8fa0e5c7-3d8e-4015-9900-3631b13a0ccb2 URI |
024 | 7 | a https://doi.org/10.1200/JCO.23.004522 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2379723252 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1584100772 URI |
040 | a (SwePub)lud (SwePub)kid (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Heymer, Emma J.u University of Birmingham4 aut |
245 | 1 0 | a Cumulative Absolute Risk of Subsequent Colorectal Cancer After Abdominopelvic Radiotherapy Among Childhood Cancer Survivors : A PanCareSurFup Study |
264 | 1 | c 2024 |
300 | a 12 s. | |
520 | a PURPOSE Childhood cancer survivors are at the risk of developing subsequent colorectal cancers (CRCs), but the absolute risks by treatment modality are uncertain. We quantified the absolute risks by radiotherapy treatment characteristics using clinically accessible data from a Pan-European wide case-control study nested within a large cohort of childhood cancer survivors: the PanCareSurFup Study. METHODS Odds ratios (ORs) from a case-control study comprising 143 CRC cases and 143 controls nested within a cohort of 69,460 survivors were calculated. These, together with standardized incidence ratios for CRC for this cohort and European general population CRC incidence rates and survivors' mortality rates, were used to estimate cumulative absolute risks (CARs) by attained age for different categories of radiation to the abdominopelvic area. RESULTS Overall, survivors treated with abdominopelvic radiotherapy treatment (ART) were three times more likely to develop a subsequent CRC than those who did not receive ART (OR, 3.1 [95% CI, 1.4 to 6.6]). For male survivors treated with ART, the CAR was 0.27% (95% CI, 0.17 to 0.59) by age 40 years, 1.08% (95% CI, 0.69 to 2.34) by age 50 years (0.27% expected in the general population), and 3.7% (95% CI, 2.36 to 7.80) by age 60 years (0.95% expected). For female survivors treated with ART, the CAR was 0.29% (95% CI, 0.18 to 0.62) by age 40 years, 1.03% (95% CI, 0.65 to 2.22) by age 50 years (0.27% expected), and 3.0% (95% CI, 1.91 to 6.37) by age 60 years (0.82% expected). CONCLUSION We demonstrated that by age 40 years survivors of childhood cancer treated with ART already have a similar risk of CRC as those age 50 years in the general population for whom population-based CRC screening begins in many countries. This information should be used in the development of survivorship guidelines for the risk stratification of survivors concerning CRC risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Jóźwiak, Katarzyna4 aut |
700 | 1 | a Kremer, Leontien C.u Princess Maxima Center for Pediatric Oncology/Hematology,Academic Medical Center of University of Amsterdam (AMC)4 aut |
700 | 1 | a Winter, David L.u University of Birmingham4 aut |
700 | 1 | a de Vathaire, Florentu Centre for Research in Epidemiology and Population Health (CESP)4 aut |
700 | 1 | a Sunguc, Cerenu University of Birmingham4 aut |
700 | 1 | a Sugden, Elaineu University of Birmingham4 aut |
700 | 1 | a Kok, Judith L.u Princess Maxima Center for Pediatric Oncology/Hematology4 aut |
700 | 1 | a van der Pal, Helena J.H.u Princess Maxima Center for Pediatric Oncology/Hematology4 aut |
700 | 1 | a Hjorth, Larsu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital4 aut0 (Swepub:lu)pedi-lhj |
700 | 1 | a Jakab, Zsuzsannau Semmelweis University4 aut |
700 | 1 | a Maule, Milena M.u Karolinska Institutet4 aut |
700 | 1 | a Haupt, Riccardou Gaslini Children's Hospital4 aut |
700 | 1 | a Bagnasco, Francescau Gaslini Children's Hospital4 aut |
700 | 1 | a Terenziani, Monicau Istituto Nazionale dei Tumori4 aut |
700 | 1 | a Diallo, Ibrahimau Centre for Research in Epidemiology and Population Health (CESP)4 aut |
700 | 1 | a Gunnes, Maria W.u Norwegian Radium Hospital,Cancer Registry of Norway, Institute of Population-Based Cancer Research4 aut |
700 | 1 | a Sommer, Gritu University of Bern4 aut |
700 | 1 | a Zaletel, Lorna Zadravecu Institute of Oncology, Ljubljana4 aut |
700 | 1 | a Kuehni, Claudia E.u University Children's Hospital Bern,University of Bern4 aut |
700 | 1 | a Winther, Jeanette F.u Aarhus University Hospital,Danish Cancer Society4 aut |
700 | 1 | a Lähteenmäki, Päivi M.u Turku University Hospital4 aut |
700 | 1 | a Gudmundsdottir, Thorgerduru Danish Cancer Society,National University Hospital of Iceland4 aut |
700 | 1 | a Allodji, Rodrigue S.u Centre for Research in Epidemiology and Population Health (CESP)4 aut |
700 | 1 | a Skinner, Rodericku University of Newcastle upon Tyne4 aut |
700 | 1 | a Ronckers, Cécile M.u Princess Maxima Center for Pediatric Oncology/Hematology,Carl von Ossietzky University of Oldenburg4 aut |
700 | 1 | a Hawkins, Michael M.u University of Birmingham4 aut |
700 | 1 | a Reulen, Raoul C.u University of Birmingham4 aut |
700 | 1 | a Teepen, Jop C.u Princess Maxima Center for Pediatric Oncology/Hematology4 aut |
710 | 2 | a University of Birminghamb Princess Maxima Center for Pediatric Oncology/Hematology4 org |
773 | 0 | t Journal of Clinical Oncologyg 42:3, s. 336-347q 42:3<336-347x 0732-183X |
773 | 0 | t Journal of clinical oncology : official journal of the American Society of Clinical Oncologyg 42:3, s. 336-347q 42:3<336-347x 1527-7755 |
856 | 4 | u http://dx.doi.org/10.1200/JCO.23.00452y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/8fa0e5c7-3d8e-4015-9900-3631b13a0ccb |
856 | 4 8 | u https://doi.org/10.1200/JCO.23.00452 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:237972325 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:158410077 |
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