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Microwave-Assisted ...
Microwave-Assisted Semisynthesis and Leishmanicidal Activity of Some Phenolic Constituents from Lichens
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- Castañeta, Grover (författare)
- Higher University of San Andrés
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- Villagomez, Rodrigo (författare)
- Higher University of San Andrés
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- Salamanca, Efrain (författare)
- Higher University of San Andrés
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- Canaviri-Paz, Pamela (författare)
- Lund University,Lunds universitet,Avdelningen för livsmedel och läkemedel,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Food and Pharma,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Bravo, José A. (författare)
- Higher University of San Andrés
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- Vila, José L. (författare)
- Higher University of San Andrés
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- Bárcenas-Pérez, Daniela (författare)
- University of South Bohemia,Institute of Microbiology of the Academy of Sciences of the Czech Republic
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- Cheel, José (författare)
- Institute of Microbiology of the Academy of Sciences of the Czech Republic
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- Sepúlveda, Beatriz (författare)
- Andrés Bello National University
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- Giménez, Alberto (författare)
- Higher University of San Andrés
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- Areche, Carlos (författare)
- University of Chile
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: separations. - 2297-8739. ; 10:10
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Leishmaniasis is considered one of the most untreated tropical diseases in the world. In this study, we investigated the in vitro leishmanicidal activity and cytotoxicity of various isolated lichen substances, including atranorin (1), usnic acid (2), gyrophoric acid (3), salazinic acid (4), galbinic acid (5), and parietin (6), and some semi-synthetic imine derivatives of usnic acid (7, 8, 9) and atranorin (10, 11, 12, 13). Imine condensation reactions with hydrazine and several amines were assisted by microwave heating, an efficient and eco-friendly energy source. The most interesting result was obtained for compound 2, which has high leishmanicidal activity but also high cytotoxicity. This cytotoxicity was mitigated in its derivative, 9, with better selectivity and high antileishmanic activity. This result may indicate that the usnic acid derivative (9) obtained using condensation with two cyclohexylamine groups is a promising lead compound for the discovery of new semisynthetic antiparasitic drugs.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- atranorin derivatives
- cytotoxicity
- green chemistry
- imine
- leishmania
- pyrazoline
- usnic acid derivatives
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Castañeta, Grove ...
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Villagomez, Rodr ...
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Salamanca, Efrai ...
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Canaviri-Paz, Pa ...
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Bravo, José A.
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Vila, José L.
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visa fler...
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Bárcenas-Pérez, ...
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Cheel, José
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Sepúlveda, Beatr ...
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Giménez, Alberto
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Areche, Carlos
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Organisk kemi
- Artiklar i publikationen
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separations
- Av lärosätet
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Lunds universitet