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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003885naa a2200409 4500
001oai:lup.lub.lu.se:9173709b-a038-4e93-8555-a6cd80d4a224
003SwePub
008160401s2009 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/15321742 URI
0247 a https://doi.org/10.1089/cbr.2009.06282 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Back, Tom4 aut
2451 0a Glomerular Filtration Rate After Alpha-Radioimmunotherapy with At-211-MX35-F(ab ')(2): A Long-Term Study of Renal Function in Nude Mice
264 1b Mary Ann Liebert Inc,c 2009
520 a Besides bone marrow, the kidneys are often dose-limiting organs in internal radiotherapy. The effects of high-linear energy transfer (LET) radiation on the kidneys after alpha-radioimmunotherapy (alpha-RIT) with the alpha-particle emitter, At-211, were studied in nude mice by serial measurements of the glomerular filtration rate (GFR). The renal toxicity was evaluated at levels close to the dose limit for the bone marrow and well within the range for therapeutic efficacy on tumors. Astatinated MX35-F(ab ')(2) monoclonal antibodies were administered intravenously to nude mice. Both non-tumor-bearing animals and animals bearing subcutaneous xenografts of the human ovarian cancer cell line, OVCAR-3, were used. The animals received approximately 0.4, 0.8, or 1.2MBq in one, two, or three fractions. The mean absorbed doses to the kidneys ranged from 1.5 to 15 Gy. The renal function was studied by serial GFR measurements, using plasma clearance of Cr-51-EDTA, up to 67 weeks after the first astatine injection. A dose-dependent effect on GFR was found and at the time interval 8-30 weeks after the first administration of astatine, the absorbed doses causing a 50% decrease in GFR were 16.4 +/- 3.3 and 14.0 +/- 4.1 Gy (mean +/- SEM), tumor-and non-tumor-bearing animals, respectively. The reduction in GFR progressed with time, and at the later time interval, (31-67 weeks) the corresponding absorbed doses were 7.5 +/- 2.4 and 11.3 +/- 2.3 Gy, respectively, suggesting that the effects of radiation on the kidneys were manifested late. Examination of the kidney sections showed histologic changes that were overall subdued. Following a-RIT with 211 At-MX35-F(ab')(2) at levels close to the dose limit of severe myelotoxicity, the effects found on renal function were relatively small, with only minor to moderate reductions in GFR. These results suggest that a mean absorbed dose to the kidneys of approximately 10Gy is acceptable, and that the kidneys would not be the primary dose-limiting organ in systemic a-RIT when using At-211-MX35-F(ab')(2).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a rate
653 a glomerular filtration
653 a renal function
653 a astatine-211
653 a radioimmunotherapy
7001 a Haraldsson, Boerje4 aut
7001 a Hultborn, Ragnar4 aut
7001 a Jensen, Holger4 aut
7001 a Johansson, Martinu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-mim
7001 a Lindegren, Sture4 aut
7001 a Jacobsson, Lars4 aut
7102 a Patologi, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t Cancer Biotherapy & Radiopharmaceuticalsd : Mary Ann Liebert Incg 24:6, s. 649-658q 24:6<649-658x 1557-8852x 1084-9785
8564 u http://dx.doi.org/10.1089/cbr.2009.0628y FULLTEXT
8564 8u https://lup.lub.lu.se/record/1532174
8564 8u https://doi.org/10.1089/cbr.2009.0628

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