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Sökning: onr:"swepub:oai:lup.lub.lu.se:947ec241-eaf6-4032-bd36-9b75bd6d4629" > The major histocomp...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003542naa a2200433 4500
001oai:lup.lub.lu.se:947ec241-eaf6-4032-bd36-9b75bd6d4629
003SwePub
008160404s2011 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/17778332 URI
0247 a https://doi.org/10.1111/j.1365-3083.2010.02493.x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Wang, Feng4 aut
2451 0a The major histocompatibility complex (MHC) of the secondary transplant tissue donor influences the cross-reactivity of alloreactive memory cells.
264 c 2011-02-08
264 1b Wiley,c 2011
520 a Memory cells are currently thought to be a major barrier to tolerance induction in transplantation. However, whether alloreactive memory cells resulting from a primary transplant have cross-reactivity in a second transplant is unclear. Here, we used skin transplantation from BALB/c mice donors to pre-sensitize C(57) BL/6 (B6) mice. One month later, several strains of mice (including BALB/c, DBA/2, NOD, C3H and B6 mice) were chosen as donors to construct a memory model of heterotopic cardiac transplantation. The higher degree of MHC mismatch to sensitizing MHC resulted in longer Median survival times (MSTs, BALB/c 3.63 days VS C3H 6.08 days). 3.5 days after cardiac transplantation, compared with the BALB/c and DBA/2 groups, in the groups of NOD and C3H, the infiltration of inflammatory cells in the grafts, the proportion and proliferation of memory cells in spleens, and the function of allogeneic antibodies decreased significantly. The varying degrees of MHC mismatch between the primary and secondary donors influenced the intensity of alloreactive memory cell function, the higher degree of MHC mismatch resulted in better tolerance during secondary transplantation, and these may be related to the changed activation, proliferation and function of the alloreactive memory cells.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a Chen, Jibing4 aut
7001 a Shao, Wei4 aut
7001 a Kang, Xiangpeng4 aut
7001 a Xu, Shuo4 aut
7001 a Xia, Junjie4 aut
7001 a Dai, Helong4 aut
7001 a Peng, Yuanzheng4 aut
7001 a Thorlacius, Henriku Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-hth
7001 a Xing, Jinchun4 aut
7001 a Qi, Zhongquanu Lund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-zq0
7102 a Kirurgib Forskargrupper vid Lunds universitet4 org
7730 t Scandinavian Journal of Immunologyd : Wileyg 73, s. 190-197q 73<190-197x 1365-3083x 0300-9475
8564 u http://www.ncbi.nlm.nih.gov/pubmed/21204892?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1111/j.1365-3083.2010.02493.xy FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-3083.2010.02493.x
8564 8u https://lup.lub.lu.se/record/1777833
8564 8u https://doi.org/10.1111/j.1365-3083.2010.02493.x

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