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Mature murine megak...
Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets
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- Zufferey, Anne (författare)
- Saint Michael's Hospital
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- Speck, Edwin R (författare)
- Saint Michael's Hospital
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- Machlus, Kellie R (författare)
- Harvard Medical School
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- Aslam, Rukhsana (författare)
- Saint Michael's Hospital
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- Guo, Li (författare)
- Saint Michael's Hospital
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- McVey, Mark J (författare)
- University of Toronto
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- Kim, Michael (författare)
- Saint Michael's Hospital
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- Kapur, Rick (författare)
- Saint Michael's Hospital,Canadian Blood Services
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- Boilard, Eric (författare)
- Laval University
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- Italiano Jr., Joseph E. (författare)
- Harvard Medical School
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- Semple, John W (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Trombocyt immunologi,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Platelet Immunology,Lund University Research Groups,Canadian Blood Services,Saint Michael's Hospital,University of Toronto
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(creator_code:org_t)
- 2017-09-08
- 2017
- Engelska 13 s.
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 1:20, s. 1773-1785
- Relaterad länk:
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http://dx.doi.org/10...
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https://ashpublicati...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Megakaryocytes (MKs) are bone marrow-derived cells that are primarily responsible for generating platelets for the maintenance of hemostasis. Although MK can variably express major histocompatibility complex (MHC) class I and II molecules during their differentiation, little is known whether they can elicit nonhemostatic immune functions such as T-cell activation. Here, we demonstrate that mature CD342 MHC class II2 CD411 MKs can endocytose exogenous ovalbumin (OVA) and proteolytically generate its immunogenic peptide ligand, which is crosspresented on their surface in association with MHC class I molecules. This crosspresentation triggered in vitro and in vivo OVA-specific CD81 T-cell activation and proliferation. In addition, the OVA-MHC class I complexes were transferred from MK to pro-platelets upon thrombopoiesis in vitro. MK could also present endogenous MK-associated (CD61) peptides to activate CD61-specific CD81 T cells and mediate immune thrombocytopenia in vivo. These results suggest that, in addition to their hemostatic role, mature MKs can significantly affect antigen-specific CD81 T-cell responses via antigen presentation and are able to spread this immunogenic information through platelets.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zufferey, Anne
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Speck, Edwin R
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Machlus, Kellie ...
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Aslam, Rukhsana
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Guo, Li
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McVey, Mark J
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visa fler...
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Kim, Michael
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Kapur, Rick
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Boilard, Eric
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Italiano Jr., Jo ...
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Semple, John W
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
- Artiklar i publikationen
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Blood Advances
- Av lärosätet
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Lunds universitet