Sökning: onr:"swepub:oai:lup.lub.lu.se:9a1c1689-120f-45bb-828f-604faf16ce80" > Functional Variants...
Fältnamn | Indikatorer | Metadata |
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000 | 04397naa a2200601 4500 | |
001 | oai:lup.lub.lu.se:9a1c1689-120f-45bb-828f-604faf16ce80 | |
003 | SwePub | |
008 | 160404s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/16260142 URI |
024 | 7 | a https://doi.org/10.3899/jrheum.0912592 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Alizadeh, Behrooz Z4 aut |
245 | 1 0 | a Functional Variants of Fc Gamma Receptor (FCGR2A) and FCGR3A Are Not Associated with Susceptibility to Systemic Sclerosis in a Large European Study (EUSTAR). |
264 | c 2010-06-15 | |
264 | 1 | b The Journal of Rheumatology,c 2010 |
520 | a OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>C functional variants in 6 independent European cohorts of white patients with SSc, and white controls. The cohorts comprised 165 Dutch patients with SSc and 1326 controls, 236 Spanish patients with SSc and 257 controls, 267 German patients with SSc and 270 controls, 202 Swedish patients with SSc and 261 controls, 416 Italian patients with SSc and 157 controls, and additionally 280 English patients with SSc. Genotyping was performed using Taqman 5' allelic discrimination assay. The study reached a 99% power to detect the effect of a polymorphism at an OR of 1.3. RESULTS: Neither FCGR2A 519A>G nor FCGR3A 559A>C was significantly associated with susceptibility to SSc. We did not find an association with specific disease phenotypes, limited or diffuse cutaneous involvement, autoantibody profiles, or pulmonary involvement. CONCLUSION: Our study strongly suggests the lack of a role for the FCGR2A 519A>G and FCGR3A 559A>C polymorphisms in SSc susceptibility or clinical phenotype in 6 independent European cohorts. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
700 | 1 | a Broen, Jasper4 aut |
700 | 1 | a Rueda, Blanca4 aut |
700 | 1 | a Hesselstrand, Rogeru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-rhe |
700 | 1 | a Wuttge, Dirku Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-dwu |
700 | 1 | a Simeon, Carmen4 aut |
700 | 1 | a Ortego-Centeno, Norberto4 aut |
700 | 1 | a Gonzalez-Gay, Miguel4 aut |
700 | 1 | a Pros, Anna4 aut |
700 | 1 | a Herrick, Ariane4 aut |
700 | 1 | a Worthington, Jane4 aut |
700 | 1 | a Denton, Christopher4 aut |
700 | 1 | a Fonseca, Carmen4 aut |
700 | 1 | a Riemekasten, Gabriela4 aut |
700 | 1 | a Vonk, Madelon C4 aut |
700 | 1 | a van den Hoogen, Frank4 aut |
700 | 1 | a Guiducci, Serena4 aut |
700 | 1 | a Matucci-Cerinic, Marco4 aut |
700 | 1 | a Scorza, Rafaella4 aut |
700 | 1 | a Beretta, Lorenzo4 aut |
700 | 1 | a Airó, Paolo4 aut |
700 | 1 | a Coenen, Marieke4 aut |
700 | 1 | a Martin, Javier4 aut |
700 | 1 | a Koeleman, Bobby P C4 aut |
700 | 1 | a Radstake, Timothy R D J4 aut |
710 | 2 | a Reumatologi och molekylär skelettbiologib Sektion III4 org |
773 | 0 | t Journal of Rheumatologyd : The Journal of Rheumatologyg Jul 1, s. 1673-1679q Jul 1<1673-1679x 0315-162Xx 1499-2752 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/20551103?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.3899/jrheum.091259y FULLTEXT |
856 | 4 | u https://www.jrheum.org/content/jrheum/37/8/1673.full.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/1626014 |
856 | 4 8 | u https://doi.org/10.3899/jrheum.091259 |
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