Sökning: onr:"swepub:oai:lup.lub.lu.se:9c67d6aa-7f70-4533-9716-c3a7a987f226" > Kinetic fingerprint...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04554naa a2200493 4500 | |
001 | oai:lup.lub.lu.se:9c67d6aa-7f70-4533-9716-c3a7a987f226 | |
003 | SwePub | |
008 | 201028s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/9c67d6aa-7f70-4533-9716-c3a7a987f2262 URI |
024 | 7 | a https://doi.org/10.1038/s41594-020-0505-62 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Linse, Sarau Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)fkm2-sli |
245 | 1 0 | a Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies |
264 | c 2020-09-28 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
300 | a 9 s. | |
520 | a The amyloid cascade hypothesis, according to which the self-assembly of amyloid-β peptide (Aβ) is a causative process in Alzheimer’s disease, has driven many therapeutic efforts for the past 20 years. Failures of clinical trials investigating Aβ-targeted therapies have been interpreted as evidence against this hypothesis, irrespective of the characteristics and mechanisms of action of the therapeutic agents, which are highly challenging to assess. Here, we combine kinetic analyses with quantitative binding measurements to address the mechanism of action of four clinical stage anti-Aβ antibodies, aducanumab, gantenerumab, bapineuzumab and solanezumab. We quantify the influence of these antibodies on the aggregation kinetics and on the production of oligomeric aggregates and link these effects to the affinity and stoichiometry of each antibody for monomeric and fibrillar forms of Aβ. Our results reveal that, uniquely among these four antibodies, aducanumab dramatically reduces the flux of Aβ oligomers. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
700 | 1 | a Scheidt, Tomu University of Cambridge4 aut |
700 | 1 | a Bernfur, Katjau Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)biok-kbe |
700 | 1 | a Vendruscolo, Micheleu University of Cambridge4 aut |
700 | 1 | a Dobson, Christopher M.u University of Cambridge4 aut |
700 | 1 | a Cohen, Samuel I.A.u Wren Therapeutics Ltd.4 aut |
700 | 1 | a Sileikis, Eimantasu Lund University4 aut |
700 | 1 | a Lundqvist, Martinu Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)bpc-mrl |
700 | 1 | a Qian, Fangu Biogen, Inc.4 aut |
700 | 1 | a O’Malley, Tiernanu Biogen, Inc.4 aut |
700 | 1 | a Bussiere, Thierryu Biogen, Inc.4 aut |
700 | 1 | a Weinreb, Paul H.u Biogen, Inc.4 aut |
700 | 1 | a Xu, Catherine K.u University of Cambridge4 aut |
700 | 1 | a Meisl, Georgu University of Cambridge4 aut |
700 | 1 | a Devenish, Sean R.A.u Fluidic Analytics Limited4 aut |
700 | 1 | a Knowles, Tuomas P.J.u University of Cambridge4 aut |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
710 | 2 | a Biokemi och Strukturbiologib Centrum för Molekylär Proteinvetenskap4 org |
773 | 0 | t Nature Structural and Molecular Biologyd : Springer Science and Business Media LLCg 27:12, s. 1125-1133q 27:12<1125-1133x 1545-9993x 1545-9985 |
856 | 4 | u http://dx.doi.org/10.1038/s41594-020-0505-6y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/9c67d6aa-7f70-4533-9716-c3a7a987f226 |
856 | 4 8 | u https://doi.org/10.1038/s41594-020-0505-6 |
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