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Successful aging : ...
Successful aging : Insights from proteome analyses of healthy centenarians
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- Santos-Lozano, Alejandro (författare)
- European University Miguel de Cervantes,12 de Octubre University Hospital
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- Valenzuela, Pedro L. (författare)
- University of Alcalá
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- Llavero, Francisco (författare)
- Achucarro - Basque Center for Neuroscience
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- Lista, Simone (författare)
- Brain and Spine Institute (ICM),Paris-Sorbonne University,Pitié-Salpêtrière University Hospital
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- Carrera-Bastos, Pedro (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Skåne University Hospital,NutriScience-Education and Consulting,Center for Primary Health Care Research
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- Hampel, Harald (författare)
- Paris-Sorbonne University
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- Pareja-Galeano, Helios (författare)
- European University of Madrid
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- Gálvez, Beatriz G. (författare)
- European University of Madrid
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- López, Juan Antonio (författare)
- Centro Nacional de Investigaciones Cardiovasculares Carlos III,Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
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- Vázquez, Jesús (författare)
- Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV),Centro Nacional de Investigaciones Cardiovasculares Carlos III
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- Emanuele, Enzo (författare)
- 2E Science
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- Zugaza, José L. (författare)
- University of the Basque Country,Achucarro - Basque Center for Neuroscience,Basque Foundation for Science
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- Lucia, Alejandro (författare)
- European University of Madrid,Spanish Center for Biomedical Research Network in Oncology (CIBERONC),European University Miguel de Cervantes
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(creator_code:org_t)
- 2020-02-25
- 2020
- Engelska.
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Ingår i: Aging. - : Impact Journals, LLC. - 1945-4589. ; 12:4, s. 3502-3515
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Healthy aging depends on a complex gene-environment network that is ultimately reflected in the expression of different proteins. We aimed to perform a comparative analysis of the plasma proteome of healthy centenarians (n=9, 5 women, age range 100-103 years) with a notably preserved ambulatory capacity (as a paradigm of 'successful' aging), and control individuals who died from a major age-related disease before the expected life expectancy (n=9, 5 women, age range: 67-81 years), and while having impaired ambulatory capacity (as a paradigm of 'unsuccessful' aging). We found that the expression of 49 proteins and 86 pathways differed between the two groups. Overall, healthy centenarians presented with distinct expression of proteins/pathways that reflect a healthy immune function, including a lower pro-inflammatory status (less 'inflammaging' and autoimmunity) and a preserved humoral immune response (increased B cell-mediated immune response). Compared with controls, healthy centenarians also presented with a higher expression of proteins involved in angiogenesis and related to enhanced intercellular junctions, as well as a lower expression of proteins involved in cardiovascular abnormalities. The identification of these proteins/pathways might provide new insights into the biological mechanisms underlying the paradigm of healthy aging.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Elderly
- Healthy aging
- Immune system
- Proteomics
- Senescence
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Aging
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Santos-Lozano, A ...
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Valenzuela, Pedr ...
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Llavero, Francis ...
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Lista, Simone
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Carrera-Bastos, ...
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Hampel, Harald
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visa fler...
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Pareja-Galeano, ...
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Gálvez, Beatriz ...
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López, Juan Anto ...
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Vázquez, Jesús
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Emanuele, Enzo
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Zugaza, José L.
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Lucia, Alejandro
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Aging
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