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Sag-rad : A Method ...
Sag-rad : A Method for Single-Cell Population Genomics of Unicellular Eukaryotes
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- Gollnisch, Raphael (författare)
- Lund University,Lunds universitet,Enhet akvatisk ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Akvatisk ekologi,Forskargrupper vid Lunds universitet,Division aquatic ecology,Department of Biology,Faculty of Science,Aquatic Ecology,Lund University Research Groups,University of Oxford
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- Wallenius, Joel (författare)
- Lund University,Lunds universitet,Klinisk neurogenetik,Forskargrupper vid Lunds universitet,Clinical Neurogenetics,Lund University Research Groups
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- Gribble, Kristin E (författare)
- Marine Biological Laboratory
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- Ahrén, Dag (författare)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Bioinformatik,Forskargrupper vid Lunds universitet,SciLifeLab Site@Lund,Molecular Cell Biology,Department of Biology,Faculty of Science,Bioinformatics,Lund University Research Groups,National Bioinformatics Infrastructure Sweden (NBIS), SciLifeLab
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- Rengefors, Karin (författare)
- Lund University,Lunds universitet,Enhet akvatisk ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Akvatisk ekologi,Forskargrupper vid Lunds universitet,Division aquatic ecology,Department of Biology,Faculty of Science,Aquatic Ecology,Lund University Research Groups
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(creator_code:org_t)
- 2023
- 2023
- Engelska 8 s.
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Ingår i: Molecular biology and evolution. - 0737-4038. ; 40:5
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Sequencing of reduced representation libraries enables genotyping of many individuals for population genomic studies. However, high amounts of DNA are required, and the method cannot be applied directly on single cells, preventing its use on most microbes. We developed and implemented the analysis of single amplified genomes followed by restriction-site-associated DNA sequencing to bypass labor-intensive culturing and to avoid culturing bias in population genomic studies of unicellular eukaryotes. This method thus opens the way for addressing important questions about the genetic diversity, gene flow, adaptation, dispersal, and biogeography of hitherto unexplored species.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Metagenomics
- Eukaryota/genetics
- Genomics/methods
- Genome
- Sequence Analysis, DNA/methods
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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