Sökning: onr:"swepub:oai:lup.lub.lu.se:9f30473f-e635-46ba-9961-1483fa454508" >
Development of a Sm...
Development of a Smart Wireless Multisensor Platform for an Optogenetic Brain Implant
-
- Cunha, André B. (författare)
- University of Oslo
-
- Schuelke, Christin (författare)
- University of Oslo
-
- Mesri, Alireza (författare)
- Polytechnic University of Milan
-
visa fler...
-
- Ruud, Simen K. (författare)
- University of Oslo
-
Aizenshtadt, Aleksandra (författare)
-
- Ferrari, Giorgio (författare)
- Polytechnic University of Milan
-
- Heiskanen, Arto (författare)
- Technical University of Denmark
-
- Asif, Afia (författare)
- Technical University of Denmark
-
- Keller, Stephan S. (författare)
- Technical University of Denmark
-
- Ramos-Moreno, Tania (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Kalvøy, Håvard (författare)
- Oslo university hospital
-
- Martínez-Serrano, Alberto (författare)
- Autonomous University of Madrid
-
- Krauss, Stefan (författare)
- Oslo university hospital
-
- Emnéus, Jenny (författare)
- Technical University of Denmark
-
- Sampietro, Marco (författare)
- Polytechnic University of Milan
-
- Martinsen, Ørjan G. (författare)
- Oslo university hospital,University of Oslo
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska.
-
Ingår i: Sensors. - 1424-8220. ; 24:2
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Implantable cell replacement therapies promise to completely restore the function of neural structures, possibly changing how we currently perceive the onset of neurodegenerative diseases. One of the major clinical hurdles for the routine implementation of stem cell therapies is poor cell retention and survival, demanding the need to better understand these mechanisms while providing precise and scalable approaches to monitor these cell-based therapies in both pre-clinical and clinical scenarios. This poses significant multidisciplinary challenges regarding planning, defining the methodology and requirements, prototyping and different stages of testing. Aiming toward an optogenetic neural stem cell implant controlled by a smart wireless electronic frontend, we show how an iterative development methodology coupled with a modular design philosophy can mitigate some of these challenges. In this study, we present a miniaturized, wireless-controlled, modular multisensor platform with fully interfaced electronics featuring three different modules: an impedance analyzer, a potentiostat and an optical stimulator. We show the application of the platform for electrical impedance spectroscopy-based cell monitoring, optical stimulation to induce dopamine release from optogenetically modified neurons and a potentiostat for cyclic voltammetry and amperometric detection of dopamine release. The multisensor platform is designed to be used as an opto-electric headstage for future in vivo animal experiments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- amperometry
- brain implant
- cyclic voltammetry
- dopamine
- electrochemistry
- impedance
- neural stem cells
- optogenetics
- Parkinson’s disease
- PSoC
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
-
Sensors
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Cunha, André B.
-
Schuelke, Christ ...
-
Mesri, Alireza
-
Ruud, Simen K.
-
Aizenshtadt, Ale ...
-
Ferrari, Giorgio
-
visa fler...
-
Heiskanen, Arto
-
Asif, Afia
-
Keller, Stephan ...
-
Ramos-Moreno, Ta ...
-
Kalvøy, Håvard
-
Martínez-Serrano ...
-
Krauss, Stefan
-
Emnéus, Jenny
-
Sampietro, Marco
-
Martinsen, Ørjan ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Sensors
- Av lärosätet
-
Lunds universitet