Sökning: onr:"swepub:oai:lup.lub.lu.se:a1559a34-b8c3-4727-9466-37c08bc4c20e" >
Clonal Hematopoiesi...
Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease
-
- Gumuser, Esra D. (författare)
- Massachusetts General Hospital
-
- Schuermans, Art (författare)
- Massachusetts Institute of Technology,Catholic University of Leuven,Massachusetts General Hospital
-
- Cho, So Mi Jemma (författare)
- Massachusetts Institute of Technology,Massachusetts General Hospital
-
visa fler...
-
- Sporn, Zachary A. (författare)
- Massachusetts General Hospital
-
- Uddin, Md Mesbah (författare)
- Massachusetts General Hospital,Massachusetts Institute of Technology
-
- Paruchuri, Kaavya (författare)
- Massachusetts Institute of Technology,Massachusetts General Hospital
-
- Nakao, Tetsushi (författare)
- Brigham and Women's Hospital / Harvard Medical School,Massachusetts Institute of Technology,Dana-Farber Cancer Institute,Massachusetts General Hospital
-
- Yu, Zhi (författare)
- Massachusetts General Hospital,Massachusetts Institute of Technology
-
- Haidermota, Sara (författare)
- Massachusetts Institute of Technology,Massachusetts General Hospital
-
- Hornsby, Whitney (författare)
- Massachusetts Institute of Technology,Massachusetts General Hospital
-
- Weeks, Lachelle D. (författare)
- Dana-Farber Cancer Institute
-
- Niroula, Abhishek (författare)
- Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Dana-Farber Cancer Institute,Massachusetts Institute of Technology
-
- Jaiswal, Siddhartha (författare)
- Stanford University School of Medicine
-
- Libby, Peter (författare)
- Brigham and Women's Hospital / Harvard Medical School
-
- Ebert, Benjamin L. (författare)
- Dana-Farber Cancer Institute
-
- Bick, Alexander G. (författare)
- Vanderbilt University Medical Center
-
- Natarajan, Pradeep (författare)
- Massachusetts General Hospital,Massachusetts Institute of Technology
-
- Honigberg, Michael C. (författare)
- Massachusetts Institute of Technology,Massachusetts General Hospital
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska 14 s.
-
Ingår i: Journal of the American College of Cardiology. - 0735-1097. ; 81:20, s. 1996-2009
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal expansion of blood stem cells with leukemia-associated mutations—is a novel cardiovascular risk factor. Whether CHIP remains prognostic in individuals with established atherosclerotic cardiovascular disease (ASCVD) is less clear. Objectives: This study tested whether CHIP predicts adverse outcomes in individuals with established ASCVD. Methods: Individuals aged 40 to 70 years from the UK Biobank with established ASCVD and available whole-exome sequences were analyzed. The primary outcome was a composite of ASCVD events and all-cause mortality. Associations of any CHIP (variant allele fraction ≥2%), large CHIP clones (variant allele fraction ≥10%), and the most commonly mutated driver genes (DNMT3A, TET2, ASXL1, JAK2, PPM1D/TP53 [DNA damage repair genes], and SF3B1/SRSF2/U2AF1 [spliceosome genes]) with incident outcomes were compared using unadjusted and multivariable-adjusted Cox regression. Results: Of 13,129 individuals (median age: 63 years) included, 665 (5.1%) had CHIP. Over a median follow-up of 10.8 years, any CHIP and large CHIP at baseline were associated with adjusted HRs of 1.23 (95% CI: 1.10-1.38; P < 0.001) and 1.34 (95% CI: 1.17-1.53; P < 0.001), respectively, for the primary outcome. TET2 and spliceosome CHIP, especially large clones, were most strongly associated with adverse outcomes (large TET2 CHIP: HR: 1.89; 95% CI: 1.40-2.55; P <0.001; large spliceosome CHIP: HR: 3.02; 95% CI: 1.95-4.70; P < 0.001). Conclusions: CHIP is independently associated with adverse outcomes in individuals with established ASCVD, with especially high risks observed in TET2 and SF3B1/SRSF2/U2AF1 CHIP.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- aging
- coronary artery disease
- inflammation
- prevention
- risk factor
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gumuser, Esra D.
-
Schuermans, Art
-
Cho, So Mi Jemma
-
Sporn, Zachary A ...
-
Uddin, Md Mesbah
-
Paruchuri, Kaavy ...
-
visa fler...
-
Nakao, Tetsushi
-
Yu, Zhi
-
Haidermota, Sara
-
Hornsby, Whitney
-
Weeks, Lachelle ...
-
Niroula, Abhishe ...
-
Jaiswal, Siddhar ...
-
Libby, Peter
-
Ebert, Benjamin ...
-
Bick, Alexander ...
-
Natarajan, Prade ...
-
Honigberg, Micha ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Journal of the A ...
- Av lärosätet
-
Lunds universitet