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Time to Peak Glucos...
Time to Peak Glucose and Peak C-Peptide During the Progression to Type 1 Diabetes in the Diabetes Prevention Trial and TrialNet Cohorts
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- Voss, Michael G. (författare)
- Indiana University-Purdue University Indianapolis
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- Cuthbertson, David D. (författare)
- University of South Florida
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- Cleves, Mario M. (författare)
- University of South Florida
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- Xu, Ping (författare)
- University of South Florida
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- Evans-Molina, Carmella (författare)
- Indiana University-Purdue University Indianapolis
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- Palmer, Jerry P. (författare)
- VA Puget Sound Health Care System
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- Redondo, Maria J. (författare)
- Baylor College of Medicine
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- Steck, Andrea K. (författare)
- University of Colorado School of Medicine
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- Lundgren, Markus (författare)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Larsson, Helena (författare)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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Moore, Wayne V. (författare)
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- Atkinson, Mark A. (författare)
- University of Florida
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- Sosenko, Jay M. (författare)
- University of Miami
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Ismail, Heba M. (författare)
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(creator_code:org_t)
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- 2021-08-06
- 2021
- Engelska 8 s.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 44:10, s. 2329-2336
- Relaterad länk:
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http://dx.doi.org/10...
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https://diabetesjour...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To assess the progression of type 1 diabetes using time to peak glucose or C-peptide during oral glucose tolerance tests (OGTTs) in autoantibody-positive relatives of people with type 1 diabetes. RESEARCH DESIGN AND METHODS: We examined 2-h OGTTs of participants in the Diabetes Prevention Trial Type 1 (DPT-1) and TrialNet Pathway to Prevention (PTP) studies. We included 706 DPT-1 participants (mean ± SD age, 13.84 ± 9.53 years; BMI Z-score, 0.33 ± 1.07; 56.1% male) and 3,720 PTP participants (age, 16.01 ± 12.33 years; BMI Z-score, 0.66 ± 1.3; 49.7% male). Log-rank testing and Cox regression analyses with adjustments (age, sex, race, BMI Z-score, HOMA-insulin resistance, and peak glucose/C-peptide levels, respectively) were performed. RESULTS: In each of DPT-1 and PTP, higher 5-year diabetes progression risk was seen in those with time to peak glucose >30 min and time to peak C-peptide >60 min (P < 0.001 for all groups), before and after adjustments. In models examining strength of association with diabetes development, associations were greater for time to peak C-peptide versus peak C-peptide value (DPT-1: χ2 = 25.76 vs. χ2 = 8.62; PTP: χ2 = 149.19 vs. χ2 = 79.98; all P < 0.001). Changes in the percentage of individuals with delayed glucose and/or C-peptide peaks were noted over time. CONCLUSIONS: In two independent at-risk populations, we show that those with delayed OGTT peak times for glucose or C-peptide are at higher risk of diabetes development within 5 years, independent of peak levels. Moreover, time to peak C-peptide appears more predictive than the peak level, suggesting its potential use as a specific biomarker for diabetes progression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Voss, Michael G.
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Cuthbertson, Dav ...
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Cleves, Mario M.
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Xu, Ping
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Evans-Molina, Ca ...
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Palmer, Jerry P.
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visa fler...
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Redondo, Maria J ...
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Steck, Andrea K.
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Lundgren, Markus
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Larsson, Helena
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Moore, Wayne V.
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Atkinson, Mark A ...
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Sosenko, Jay M.
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Ismail, Heba M.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Lunds universitet