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Effects of Levodopa...
Effects of Levodopa-Carbidopa Intestinal Gel on Dyskinesia and Non-Motor Symptoms Including Sleep : Results from a Meta-Analysis with 24-Month Follow-Up
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- Chaudhuri, K. Ray (författare)
- King's College Hospital
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- Antonini, Angelo (författare)
- University of Padova
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- Pahwa, Rajesh (författare)
- University of Kansas Medical Center
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- Odin, Per (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Titova, Nataliya (författare)
- Federal Center of Brain Research and Neurotechnologies of the FMBA of Russia,Pirogov Russian National Research Medical University (RNRMU)
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- Thakkar, Sandeep (författare)
- Hoag Hospital Newport Beach
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- Snedecor, Sonya J. (författare)
- Open Health, New York
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- Hegde, Saket (författare)
- Open Health, New York
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- Alobaidi, Ali (författare)
- AbbVie Inc.,University of Illinois at Chicago
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- Parra, Juan Carlos (författare)
- AbbVie Inc.
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- Zadikoff, Cindy (författare)
- AbbVie Inc.
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- Bergmann, Lars (författare)
- AbbVie Inc.
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- Standaert, David G. (författare)
- University of Alabama
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(creator_code:org_t)
- 2022
- 2022
- Engelska 13 s.
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Ingår i: Journal of Parkinson's Disease. - 1877-7171. ; 12:7, s. 2071-2083
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: In advanced Parkinson's disease (PD), dyskinesias and non-motor symptoms such as sleep dysfunction can significantly impair quality of life, and high-quality management is an unmet need. Objective: To analyze changes in dyskinesia and non-motor symptoms (including sleep) among studies with levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Methods: A comprehensive literature review identified relevant studies examining LCIG efficacy. Outcomes of interest were dyskinesia (UDysRS, UPDRS IV item 32), overall non-motor symptoms (NMSS), mentation/behavior/mood (UPDRS I), and sleep/daytime sleepiness (PDSS-2, ESS). The pooled mean (95% confidence interval) change from baseline per outcome was estimated for each 3-month interval with sufficient data (i.e., reported by≥3 studies) up to 24 months using a random-effects model. Results: Seventeen open-label studies evaluating 1243 patients with advanced PD were included. All outcomes of interest with sufficient data for meta-analysis showed statistically significant improvement within 6 months of starting LCIG. There were statistically significant improvements in dyskinesia duration as measured by UPDRS IV item 32 at 6 months (-1.10 [-1.69, -0.51] h/day) and 12 months (-1.35 [-2.07, -0.62] h/day). There were statistically and clinically significant improvements in non-motor symptoms as measured by NMSS scores at 3 months (-28.71 [-40.26, -17.15] points). Significant reduction of NMSS burden was maintained through 24 months (-17.61 [-21.52, -13.70] points). UPDRS I scores significantly improved at 3 months (-0.39 [-0.55, -0.22] points). Clinically significant improvements in PDSS-2 and ESS scores were observed at 6 and 12 months in individual studies. Conclusion: Patients with advanced PD receiving LCIG showed significant sustained improvements in the burden of dyskinesia and non-motor symptoms up to 24 months after initiation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- carbidopa/levodopa
- meta-analysis
- motor symptoms
- Parkinson's disease
- quality of life
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Till lärosätets databas
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Chaudhuri, K. Ra ...
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Antonini, Angelo
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Pahwa, Rajesh
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Odin, Per
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Titova, Nataliya
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Thakkar, Sandeep
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visa fler...
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Snedecor, Sonya ...
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Hegde, Saket
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Alobaidi, Ali
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Parra, Juan Carl ...
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Zadikoff, Cindy
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Bergmann, Lars
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Standaert, David ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Journal of Parki ...
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Lunds universitet