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Semantic Priming In...
Semantic Priming In Schizophrenia - The N400 In A Picture Verification Task
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- Stenberg, Georg (författare)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Carlsson, Roger (författare)
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Jonsson, Henrik (författare)
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- Johansson, Mikael (författare)
- Lund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences
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- Rosén, Ingmar (författare)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Society for Psychophysiological Research. - 0048-5772.
- Relaterad länk:
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http://www.stenberg.... (free)
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Semantic memory access has been characterized as abnormal in schizophrenia, but findings concerning automatic spreading activation at short stimulus onset asynchronies (SOA) have been inconsistent. Using the N400 as an indicator of semantic priming, a recent study (Mathalon, Faustman, & Ford, 2002) found evidence of hyperpriming in schizophrenic patients in a picture verification task. The present study replicates the Mathalon et al. study and extends the paradigm to a third stimulus condition. Pictures of common objects were shown, followed at short SOAs by words with three types of semantic relation to the picture: (a) matching, e.g. dog-dog, (b) related, e.g. dog-cat, or (c) unrelated, e.g. dog-bicycle. We expected patients to show a smaller N400 than controls in the related condition, indicating hyperpriming of semantic relations. Eighteen medicated patients and twenty-four controls participated. Behavioral results revealed slowed reaction times in patients, but no interaction with stimulus condition. The P300 in the matching condition was normal. The N400 in the related condition was, as predicted, reduced in patients. Unexpectedly, the unrelated condition showed the same difference between patients and controls, suggesting that reduced N400 was not caused by activation spreading along normal pathways. Subtraction waveforms (related - unrelated) were equivalent in amplitude between groups, but peak latency was longer in patients. The results indicate slowed processing, and an atypical pattern of semantic activation in schizophrenia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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