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Association of elev...
Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations
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- Price, David B. (författare)
- University of Aberdeen,Observational and Pragmatic Research Institute Pte Ltd
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- Bosnic-Anticevich, Sinthia (författare)
- University of Sydney
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- Pavord, Ian D. (författare)
- University of Oxford
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- Roche, Nicolas (författare)
- Paris Descartes University
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- Halpin, David M.G. (författare)
- Royal Devon & Exeter Hospital
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- Bjermer, Leif (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Usmani, Omar S. (författare)
- Imperial College London
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- Brusselle, Guy (författare)
- Ghent University Hospital
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- Ming, Simon Wan Yau (författare)
- Observational and Pragmatic Research Institute Pte Ltd
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- Rastogi, Sarang (författare)
- AstraZeneca, UK
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(creator_code:org_t)
- 2019-08-21
- 2019
- Engelska 18 s.
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Ingår i: Clinical and Translational Allergy. - : Wiley. - 2045-7022. ; 9:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://ctajournal.b...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations. Methods: This observational study included data from the Optimum Patient Care Research Database. Asthma patients (18-80 years) with valid continuous data for 1 year before FeNO reading, ≥ 1 inhaled corticosteroid prescription, and BEC recorded ≤ 5 years before FeNO reading were separated into cohorts. Categorisation 1 was based on the American Thoracic Society criteria for elevated FeNO concentration (high: ≥ 50 ppb; non-high: < 25 ppb) and BEC (high: ≥ 0.300 × 109 cells/L; non-high: < 0.300 × 109 cells/L). Categorisation 2 (FeNO concentration, high: ≥ 35 ppb; non-high: < 35 ppb) was based on prior research. Reference groups included patients with neither biomarker raised. Results: In categorisation 1, patients with either high FeNO or high BEC (n = 200) had a numerically greater exacerbation rate (unadjusted rate ratio, 1.31 [95% confidence interval: 0.97, 1.76]) compared with patients in the reference group. Combination of high FeNO and high BEC (n = 27) resulted in a significantly greater exacerbation rate (3.67 [1.49, 9.04]). Similarly, for categorisation 2, when both biomarkers were raised (n = 53), a significantly greater exacerbation rate was observed (1.72 [1.00, 2.93]). Conclusion: The combination of high FeNO and high BEC was associated with significantly increased severe exacerbation rates in the year preceding FeNO reading, suggesting that combining FeNO and BEC measurements in primary care may identify asthma patients at risk of exacerbations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Asthma
- Blood eosinophils
- Exhaled airway markers
- Nitric oxide
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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