Sökning: onr:"swepub:oai:lup.lub.lu.se:a3bb558f-a028-44a5-88aa-2154baba8cc5" > Systematic analyses...
Fältnamn | Indikatorer | Metadata |
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000 | 06549naa a2200805 4500 | |
001 | oai:lup.lub.lu.se:a3bb558f-a028-44a5-88aa-2154baba8cc5 | |
003 | SwePub | |
008 | 190611s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-161610 | |
024 | 7 | a https://lup.lub.lu.se/record/a3bb558f-a028-44a5-88aa-2154baba8cc52 URI |
024 | 7 | a https://doi.org/10.1093/carcin/bgy1872 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1616102 URI |
040 | a (SwePub)lud (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Dai, Junchengu Nanjing Medical University4 aut |
245 | 1 0 | a Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci |
264 | c 2019-01-09 | |
264 | 1 | b Oxford University Press (OUP),c 2019 |
300 | a 9 s. | |
520 | a DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in DHS-related regions. However, limited studies are available on the roles of DHS-related variants in lung cancer. In this study, we performed a large-scale case-control study with 20 871 lung cancer cases and 15 971 controls to evaluate the associations between regulatory genetic variants in DHS and lung cancer susceptibility. The expression quantitative trait loci (eQTL) analysis and pathway-enrichment analysis were performed to identify the possible target genes and pathways. In addition, we performed motif-based analysis to explore the lung-cancer-related motifs using sequence kernel association test. Two novel variants, rs186332 in 20q13.3 (C>T, odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.10-1.24, P = 8.45 × 10-7) and rs4839323 in 1p13.2 (T>C, OR = 0.92, 95% CI: 0.89-0.95, P = 1.02 × 10-6) showed significant association with lung cancer risk. The eQTL analysis suggested that these two SNPs might regulate the expression of MRGBP and SLC16A1, respectively. What's more, the expression of both MRGBP and SLC16A1 was aberrantly elevated in lung tumor tissues. The motif-based analysis identified 10 motifs related to the risk of lung cancer (P < 1.71 × 10-4). Our findings suggested that variants in DHS might modify lung cancer susceptibility through regulating the expression of surrounding genes. This study provided us a deeper insight into the roles of DHS-related genetic variants for lung cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Li, Zhihuau First Affiliated Hospital of Nanjing Medical University4 aut |
700 | 1 | a Amos, Christopher I.u Dartmouth College4 aut |
700 | 1 | a Hung, Rayjean J.u Sinai Health System,University of Toronto4 aut |
700 | 1 | a Tardon, Adoninau CIBER Epidemiology and Public Health (CIBERESP),University of Oviedo4 aut |
700 | 1 | a Andrew, Angeline S.u Norris Cotton Cancer Center4 aut |
700 | 1 | a Chen, Chuu Fred Hutchinson Cancer Research Center,Harvard University,Vanderbilt University4 aut |
700 | 1 | a Christiani, David C.u Harvard University4 aut |
700 | 1 | a Albanes, Demetriosu National Cancer Institute, USA4 aut |
700 | 1 | a van der Heijden, Erik H.F.M.u Radboud University Medical Center4 aut |
700 | 1 | a Duell, Eric J.u Catalan Institute of Oncology4 aut |
700 | 1 | a Rennert, Gadu Carmel Medical Center4 aut |
700 | 1 | a Mckay, James D.u International Agency for Research on Cancer, World Health Organization4 aut |
700 | 1 | a Yuan, Jian Minu University of Pittsburgh Cancer Institute4 aut |
700 | 1 | a Field, John K.u University of Liverpool4 aut |
700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-jma |
700 | 1 | a Grankvist, Kjellu Umeå universitet,Umeå University,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002 |
700 | 1 | a Le Marchand, Loicu University of Hawaii at Manoa4 aut |
700 | 1 | a Teare, M. Dawnu University of Sheffield4 aut |
700 | 1 | a Schabath, Matthew B.u H. Lee Moffitt Cancer Center & Research Institute4 aut |
700 | 1 | a Aldrich, Melinda C.u Vanderbilt University4 aut |
700 | 1 | a Tsao, Ming Soundu Princess Margaret Hospital University of Toronto4 aut |
700 | 1 | a Lazarus, Philipu Washington State University4 aut |
700 | 1 | a Lam, Stephenu British Columbia Cancer Agency4 aut |
700 | 1 | a Bojesen, Stig E.u University of Copenhagen,Gentofte Hospital4 aut |
700 | 1 | a Arnold, Susanneu University of Kentucky Medical Center4 aut |
700 | 1 | a Wu, Xifengu University of Texas4 aut |
700 | 1 | a Haugen, Aageu National Institute of Occupational Health, Norway4 aut |
700 | 1 | a Janout, Vladimiru Palacký University4 aut |
700 | 1 | a Johansson, Mikaelu Umeå universitet,Umeå University,Onkologi4 aut0 (Swepub:umu)mijo0025 |
700 | 1 | a Brhane, Yonathanu University of Toronto,Sinai Health System4 aut |
700 | 1 | a Fernandez-Somoano, Anau University of Oviedo,CIBER Epidemiology and Public Health (CIBERESP)4 aut |
700 | 1 | a Kiemeney, Lambertus A.u Radboud University Medical Center4 aut |
700 | 1 | a Davies, Michael P.A.u University of Liverpool4 aut |
700 | 1 | a Zienolddiny, Shanbehu National Institute of Occupational Health, Norway4 aut |
700 | 1 | a Hu, Zhibinu Nanjing Medical University4 aut |
700 | 1 | a Shen, Hongbingu Nanjing Medical University4 aut |
710 | 2 | a Nanjing Medical Universityb First Affiliated Hospital of Nanjing Medical University4 org |
773 | 0 | t Carcinogenesisd : Oxford University Press (OUP)g 40:3, s. 432-440q 40:3<432-440x 0143-3334x 1460-2180 |
856 | 4 | u http://dx.doi.org/10.1093/carcin/bgy187y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc6783905?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/a3bb558f-a028-44a5-88aa-2154baba8cc5 |
856 | 4 8 | u https://doi.org/10.1093/carcin/bgy187 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161610 |
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