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Prophylactic treatm...
Prophylactic treatment in Sweden - Overtreatment or optimal model?
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Lee, C A (författare)
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Kessler, C M (författare)
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Varon, D (författare)
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Martinowitz, U (författare)
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Heim, M (författare)
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- Ljung, R.C.R. (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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(creator_code:org_t)
- 2003-02-06
- 1998
- Engelska.
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Ingår i: Haemophilia. - : Wiley. - 1351-8216. ; 4:4, s. 409-412
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- At the haemophilia centre in Malmo, Sweden, regular prophylactic treatment is begun at 1-1 1/4 years of age, before the onset of joint bleeds. The dose and dose interval are optimised by means of pharmacokinetic studies to determine the individual patient's FVIII or IX metabolism, the goal of maintaining a level > 1% of normal being taken as a guideline which experience has shown to yield satisfactory control of bleeding diathesis. An optimal model for prophylactic treatment needs to be applicable to haemophiliacs and acceptable to health authorities in a majority of the countries in the world. To fulfill these criteria, the Swedish model, which has been shown to yield most satisfactory outcome, can hopefully be further refined in the future. Were continuous infusion, using a recombinate concentrate with a prolonged half-life, technically feasible and socially acceptable to the child, we would probably have attained the optimal model of prophylactic treatment.
Nyckelord
- Factor IX
- Factor VIII
- Haemophilia A
- Haemophilia B
- Prophylaxis
- blood clotting factor
- blood clotting factor 8
- blood clotting factor 9
- conference paper
- continuous infusion
- drug half life
- hemarthrosis
- hemophilia
- human
- metabolism
- practice guideline
- priority journal
- prophylaxis
- Sweden
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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