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Ultracompact 3D mic...
Ultracompact 3D microfluidics for time-resolved structural biology
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- Knoška, Juraj (författare)
- German Electron Synchrotron (DESY),University of Hamburg
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- Adriano, Luigi (författare)
- German Electron Synchrotron (DESY)
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- Awel, Salah (författare)
- German Electron Synchrotron (DESY),University of Hamburg
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- Beyerlein, Kenneth R. (författare)
- Max Planck Institute for the Structure and Dynamics of Matter,German Electron Synchrotron (DESY)
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- Yefanov, Oleksandr (författare)
- German Electron Synchrotron (DESY)
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- Oberthuer, Dominik (författare)
- German Electron Synchrotron (DESY)
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- Peña Murillo, Gisel E. (författare)
- German Electron Synchrotron (DESY),University of Hamburg
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- Roth, Nils (författare)
- German Electron Synchrotron (DESY),University of Hamburg
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- Sarrou, Iosifina (författare)
- German Electron Synchrotron (DESY)
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- Villanueva-Perez, Pablo (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Synkrotronljusfysik,Fysiska institutionen,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Synchrotron Radiation Research,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,German Electron Synchrotron (DESY)
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- Wiedorn, Max O. (författare)
- German Electron Synchrotron (DESY),University of Hamburg
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- Wilde, Fabian (författare)
- Helmholtz-Zentrum Geesthacht
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- Bajt, Saša (författare)
- German Electron Synchrotron (DESY)
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- Chapman, Henry N. (författare)
- German Electron Synchrotron (DESY),University of Hamburg
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- Heymann, Michael (författare)
- University of Stuttgart,German Electron Synchrotron (DESY)
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(creator_code:org_t)
- 2020-01-31
- 2020
- Engelska.
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- To advance microfluidic integration, we present the use of two-photon additive manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with nanometer precision. We demonstrate this technique by tailoring microfluidic nozzles and mixers for time-resolved structural biology at X-ray free-electron lasers (XFELs). We achieve submicron jets with speeds exceeding 160 m s−1, which allows for the use of megahertz XFEL repetition rates. By integrating an additional orifice, we implement a low consumption flow-focusing nozzle, which is validated by solving a hemoglobin structure. Also, aberration-free in operando X-ray microtomography is introduced to study efficient equivolumetric millisecond mixing in channels with 3D features integrated into the nozzle. Such devices can be printed in minutes by locally adjusting print resolution during fabrication. This technology has the potential to permit ultracompact devices and performance improvements through 3D flow optimization in all fields of microfluidic engineering.
Ämnesord
- NATURVETENSKAP -- Fysik -- Atom- och molekylfysik och optik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Atom and Molecular Physics and Optics (hsv//eng)
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- Av författaren/redakt...
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Knoška, Juraj
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Adriano, Luigi
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Awel, Salah
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Beyerlein, Kenne ...
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Yefanov, Oleksan ...
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Oberthuer, Domin ...
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visa fler...
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Peña Murillo, Gi ...
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Roth, Nils
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Sarrou, Iosifina
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Villanueva-Perez ...
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Wiedorn, Max O.
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Wilde, Fabian
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Bajt, Saša
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Chapman, Henry N ...
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Heymann, Michael
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Fysik
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och Atom och molekyl ...
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Nature Communica ...
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Lunds universitet