Sökning: onr:"swepub:oai:lup.lub.lu.se:a6102484-57c7-4f03-b0a9-c1a89d8a8ca1" >
Ciprofloxacin inter...
Ciprofloxacin intercalated in fluorohectorite clay : Identical pure drug activity and toxicity with higher adsorption and controlled release rate
-
- Dos Santos, E. C. (författare)
- Norwegian University of Science and Technology,University of Copenhagen
-
- Rozynek, Zbigniew (författare)
- Norwegian University of Science and Technology,Adam Mickiewicz University in Poznań
-
- Hansen, E. L. (författare)
- Norwegian University of Science and Technology
-
visa fler...
-
- Hartmann-Petersen, R. (författare)
- University of Copenhagen
-
- Klitgaard, R. N. (författare)
- University of Copenhagen
-
- Løbner-Olesen, A. (författare)
- University of Copenhagen
-
- Michels, Leander (författare)
- Norwegian University of Science and Technology
-
- Mikkelsen, A. (författare)
- Norwegian University of Science and Technology,Adam Mickiewicz University in Poznań
-
- Plivelic, T. S. (författare)
- Lund University,Lunds universitet,MAX IV-laboratoriet,MAX IV Laboratory
-
- Bordallo, H. N. (författare)
- Lund University,Lunds universitet,European Spallation Source ESS AB,Stiftelser och övriga anknutna verksamheter,Other Institutions and Utilities,University of Copenhagen
-
- Fossum, Jon O. (författare)
- Institute Pierre-Gilles de Gennes pour la microfluidique,Norwegian University of Science and Technology
-
visa färre...
-
(creator_code:org_t)
- 2017
- 2017
- Engelska 9 s.
-
Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 7:43, s. 26537-26545
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Different natural clay minerals, including halloysite, montmorillonite and kaolinite, have been proven to be efficient drug carriers providing for high and long lasting drug concentrations owing to their adsorption capacity and ion exchange property. Synthetic clays, however, are advantageous over the natural clay minerals in terms of purity of composition and controllable cation exchange capacity, factors that contribute to improve reproducibility of the host system. Here we studied a synthetic smectite clay as a candidate for high adsorption and controlled release rate. Via X-ray powder diffraction we verified that, under acidic conditions, the antibiotic ciprofloxacin was successfully incorporated in the synthetic clay fluorohectorite, while via UV-VIS spectroscopy we showed that the degree of the drug incorporation is at least 25% higher than for other systems reported in the literature. Furthermore, temperature dependent release studies allowed us to show that the release process is thermally activated and diffusion-controlled. Finally, via bacterial and toxicological tests, we demonstrated that the effectiveness and toxicity of pure ciprofloxacin is unaffected in the clay-drug complex.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Dos Santos, E. C ...
-
Rozynek, Zbignie ...
-
Hansen, E. L.
-
Hartmann-Peterse ...
-
Klitgaard, R. N.
-
Løbner-Olesen, A ...
-
visa fler...
-
Michels, Leander
-
Mikkelsen, A.
-
Plivelic, T. S.
-
Bordallo, H. N.
-
Fossum, Jon O.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Farmaceutiska ve ...
- Artiklar i publikationen
-
RSC Advances
- Av lärosätet
-
Lunds universitet