onr:"swepub:oai:lup.lub.lu.se:a62da20c-f3c2-4118-b8ea-ef3ef4635abd"
Sökning: onr:"swepub:oai:lup.lub.lu.se:a62da20c-f3c2-4118-b8ea-ef3ef4635abd" > Binding of vitronec...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03534naa a2200385 4500 | |
| 001 | oai:lup.lub.lu.se:a62da20c-f3c2-4118-b8ea-ef3ef4635abd | |
| 003 | SwePub | |
| 008 | 160401s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/46994062 URI |
| 024 | 7 | a https://doi.org/10.1160/TH14-06-05612 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Kohler, S4 aut |
| 245 | 1 0 | a Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3. |
| 264 | 1 | c 2015 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Streptococcus pneumoniae serotype 3 strains are highly resistant to opsonophagocytosis due to recruitment of the complement inhibitor Factor H via Hic, a member of the pneumococcal surface protein C (PspC) family. In this study, we demonstrated that Hic also interacts with vitronectin, a fluid-phase regulator involved in haemostasis, angiogenesis, and the terminal complement cascade as well as a component of the extracellular matrix. Blocking of Hic by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In parallel, ectopic expression of Hic on the surface of Lactococcus lactis conferred binding to soluble and immobilised vitronectin as well as Factor H. Molecular analyses with truncated Hic fragments narrowed down the vitronectin-binding site to the central core of Hic (aa 151-201). This vitronectin-binding region is separate from that of Factor H, which binds to the N-terminus of Hic (aa 38-92). Binding of pneumococcal Hic was localised to the C-terminal heparin-binding domain (HBD3) of vitronectin. However, an N-terminal region to HBD3 was further involved in Hic-binding to immobilised vitronectin. Finally, vitronectin bound to Hic was functionally active and inhibited formation of the terminal complement complex. In conclusion, Hic interacts with vitronectin and simultaneously with Factor H, and both human proteins may contribute to colonisation and invasive disease caused by serotype 3 pneumococci. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 700 | 1 | a Hallström, T4 aut |
| 700 | 1 | a Singh, Birendrau Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-bas |
| 700 | 1 | a Riesbeck, Kristianu Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-kri |
| 700 | 1 | a Sparta, G4 aut |
| 700 | 1 | a Zipfel, P F4 aut |
| 700 | 1 | a Hammerschmidt, S4 aut |
| 710 | 2 | a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Thrombosis and Haemostasisg 113:1, s. 125-142q 113:1<125-142x 0340-6245 |
| 856 | 4 | u https://portal.research.lu.se/files/3626254/5384801.pdfx primaryx freey FULLTEXT |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25181963?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1160/TH14-06-0561y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4699406 |
| 856 | 4 8 | u https://doi.org/10.1160/TH14-06-0561 |
Hitta via bibliotek
- Thrombosis and Haemostasis (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Kohler, S
- Hallström, T
- Singh, Birendra
- Riesbeck, Kristi ...
- Sparta, G
- Zipfel, P F
- visa fler...
- Hammerschmidt, S
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Kardiologi
- Artiklar i publikationen
- Thrombosis and H ...
- Av lärosätet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
