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Incidence of Pediat...
Incidence of Pediatric Celiac Disease Varies by Region
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- Stahl, Marisa (författare)
- University of Colorado School of Medicine
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- Li, Qian (författare)
- St Jude Children´s Research Hospital, Memphis
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- Lynch, Kristian (författare)
- University of South Florida
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- Koletzko, Sibylle (författare)
- University Hospital Munich,University of Warmia and Mazury
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- Mehta, Pooja (författare)
- University of Colorado School of Medicine
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- Gragert, Loren (författare)
- Tulane University School of Medicine
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- Norris, Jill M. (författare)
- Colorado School of Public Health
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- Andrén Aronsson, Carin (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Lindfors, Katri (författare)
- University of Tampere
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- Kurppa, Kalle (författare)
- University of Tampere
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- Ilonen, Jorma (författare)
- University of Turku
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- Krischer, Jeffrey (författare)
- University of South Florida
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- Alkolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases,Turku University Hospital
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- Ziegler, Anette G. (författare)
- Helmholtz Zentrum München
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- Toppari, Jorma (författare)
- University of Turku
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- Rewers, Marian J. (författare)
- Barbara Davis Center for Childhood Diabetes
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- Agardh, Daniel (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Hagopian, William (författare)
- Pacific Northwest Research Institute
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- Liu, Edwin (författare)
- University of Colorado School of Medicine
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(creator_code:org_t)
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- 2022-10-11
- 2023
- Engelska 7 s.
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Ingår i: American Journal of Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 0002-9270 .- 1572-0241. ; 118:3, s. 539-545
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- INTRODUCTION:The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions within Europe and the United States. Our aim was to identify regional differences in CD autoimmunity and CD cumulative incidence for children born between 2004 and 2010.METHODS:Children (n = 6,628) with DQ2.5 and/or DQ8.1 were enrolled prospectively from birth in Georgia, Washington, Colorado, Finland, Germany, and Sweden. Children underwent periodic study screening for tissue transglutaminase antibodies and then CD evaluation per clinical care. Population-specific estimates were calculated by weighting the study-specific cumulative incidence with the population-specific haplogenotype frequencies obtained from large stem cell registries from each site.RESULTS:Individual haplogenotype risks for CD autoimmunity and CD varied by region and affected the cumulative incidence within that region. The CD incidence by age 10 years was highest in Swedish children at 3%. Within the United States, the incidence by age 10 years in Colorado was 2.4%. In the model adjusted for HLA, sex, and family history, Colorado children had a 2.5-fold higher risk of CD compared to Washington. Likewise, Swedish children had a 1.4-fold and 1.8-fold higher risk of CD compared with those in Finland and Germany, respectively.DISCUSSION:There is high regional variability in cumulative incidence of CD, which suggests differential environmental, genetic, and epigenetic influences even within the United States. The overall high incidence warrants a low threshold for screening and further research on region-specific CD triggers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Stahl, Marisa
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Li, Qian
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Lynch, Kristian
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Koletzko, Sibyll ...
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Mehta, Pooja
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Gragert, Loren
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visa fler...
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Norris, Jill M.
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Andrén Aronsson, ...
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Lindfors, Katri
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Kurppa, Kalle
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Ilonen, Jorma
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Krischer, Jeffre ...
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Alkolkar, Beena
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Ziegler, Anette ...
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Toppari, Jorma
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Rewers, Marian J ...
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Agardh, Daniel
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Hagopian, Willia ...
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Liu, Edwin
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