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Association of mito...
Association of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women : A population-based follow-up study
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- Memon, Ashfaque A (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Wallenberglaboratoriet, Malmö,Medicinska fakulteten,Family Medicine and Clinical Epidemiology,Lund University Research Groups,The Wallenberg Laboratory, Malmö,Faculty of Medicine,Center for Primary Health Care Research,Skåne University Hospital
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- Sundquist, Jan (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Wallenberglaboratoriet, Malmö,Medicinska fakulteten,Family Medicine and Clinical Epidemiology,Lund University Research Groups,The Wallenberg Laboratory, Malmö,Faculty of Medicine,Center for Primary Health Care Research,Skåne University Hospital
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- Hedelius, Anna (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Wallenberglaboratoriet, Malmö,Medicinska fakulteten,Family Medicine and Clinical Epidemiology,Lund University Research Groups,The Wallenberg Laboratory, Malmö,Faculty of Medicine,Skåne University Hospital,Center for Primary Health Care Research
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- Palmér, Karolina (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Wallenberglaboratoriet, Malmö,Medicinska fakulteten,Family Medicine and Clinical Epidemiology,Lund University Research Groups,The Wallenberg Laboratory, Malmö,Faculty of Medicine,Skåne University Hospital,Center for Primary Health Care Research
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- Wang, Xiao (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Wallenberglaboratoriet, Malmö,Medicinska fakulteten,Family Medicine and Clinical Epidemiology,Lund University Research Groups,The Wallenberg Laboratory, Malmö,Faculty of Medicine,Skåne University Hospital,Center for Primary Health Care Research
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- Sundquist, Kristina (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Wallenberglaboratoriet, Malmö,Medicinska fakulteten,Family Medicine and Clinical Epidemiology,Lund University Research Groups,The Wallenberg Laboratory, Malmö,Faculty of Medicine,Center for Primary Health Care Research,Skåne University Hospital
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(creator_code:org_t)
- 2021-02-25
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction and is associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict the risk of developing T2DM is not well-known. We quantified absolute mtDNA-CN in both prevalent and incident T2DM by well-optimized droplet digital PCR (ddPCR) method in a population-based follow-up study of middle aged (50-59 years) Swedish women (n = 2387). The median follow-up period was 17 years. Compared to those who were free of T2DM, mtDNA-CN was significantly lower in both prevalent T2DM and in women who developed T2DM during the follow-up period. Mitochondrial DNA-copy number was also associated with glucose intolerance, systolic blood pressure, smoking status and education. In multivariable Cox regression analysis, lower baseline mtDNA-CN was prospectively associated with a higher risk of T2DM, independent of age, BMI, education, smoking status and physical activity. Moreover, interaction term analysis showed that smoking increased the effect of low mtDNA-CN at baseline on the risk of incident T2DM. Mitochondrial DNA-copy number may be a risk factor of T2DM in women. The clinical usefulness of mtDNA-CN to predict the future risk of T2DM warrants further investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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