Sökning: onr:"swepub:oai:lup.lub.lu.se:a8f6b683-65d8-4631-85a9-327a215a6d29" > Common Genetic Vari...
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000 | 08129naa a2201705 4500 | |
001 | oai:lup.lub.lu.se:a8f6b683-65d8-4631-85a9-327a215a6d29 | |
003 | SwePub | |
008 | 160401s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/17528612 URI |
024 | 7 | a https://doi.org/10.1371/journal.pgen.10011832 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Gaudet, Mia M.4 aut |
245 | 1 0 | a Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer |
264 | c 2010-10-28 | |
264 | 1 | b Public Library of Science (PLoS),c 2010 |
338 | a electronic2 rdacarrier | |
520 | a The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers. In stage 1 using the Affymetrix 6.0 platform, 592,163 filtered SNPs genotyped were available on 899 young (, 40 years) affected and 804 unaffected carriers of European ancestry. Associations were evaluated using a survival-based score test adjusted for familial correlations and stratified by country of the study and BRCA2*6174delT mutation status. The genomic inflation factor (lambda) was 1.011. The stage 1 association analysis revealed multiple variants associated with breast cancer risk: 3 SNPs had p-values, 10 25 and 39 SNPs had p-values<10(-4). These variants included several previously associated with sporadic breast cancer risk and two novel loci on chromosome 20 (rs311499) and chromosome 10 (rs16917302). The chromosome 10 locus was in ZNF365, which contains another variant that has recently been associated with breast cancer in an independent study of unselected cases. In stage 2, the top 85 loci from stage 1 were genotyped in 1,264 cases and 1,222 controls. Hazard ratios (HR) and 95% confidence intervals (CI) for stage 1 and 2 were combined and estimated using a retrospective likelihood approach, stratified by country of residence and the most common mutation, BRCA2*6174delT. The combined per allele HR of the minor allele for the novel loci rs16917302 was 0.75 (95% CI 0.66-0.86, p = 3: 8 x 10(-5)) and for rs311499 was 0.72 (95% CI 0.61-0.85, p = 6: 6 x 10(-5)). FGFR2 rs2981575 had the strongest association with breast cancer risk (per allele HR = 1.28, 95% CI 1.18-1.39, p = 1: 2 x 10(-8)). These results indicate that SNPs that modify BRCA2 penetrance identified by an agnostic approach thus far are limited to variants that also modify risk of sporadic BRCA2 wild-type breast cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Kirchhoff, Tomas4 aut |
700 | 1 | a Green, Todd4 aut |
700 | 1 | a Vijai, Joseph4 aut |
700 | 1 | a Korn, Joshua M.4 aut |
700 | 1 | a Guiducci, Candace4 aut |
700 | 1 | a Segre, Ayellet V.4 aut |
700 | 1 | a McGee, Kate4 aut |
700 | 1 | a McGuffog, Lesley4 aut |
700 | 1 | a Kartsonaki, Christiana4 aut |
700 | 1 | a Morrison, Jonathan4 aut |
700 | 1 | a Healey, Sue4 aut |
700 | 1 | a Sinilnikova, Olga M.4 aut |
700 | 1 | a Stoppa-Lyonnet, Dominique4 aut |
700 | 1 | a Mazoyer, Sylvie4 aut |
700 | 1 | a Gauthier-Villars, Marion4 aut |
700 | 1 | a Sobol, Hagay4 aut |
700 | 1 | a Longy, Michel4 aut |
700 | 1 | a Frenay, Marc4 aut |
700 | 1 | a Hogervorst, Frans B. L.4 aut |
700 | 1 | a Rookus, Matti A.4 aut |
700 | 1 | a Collee, J. Margriet4 aut |
700 | 1 | a Hoogerbrugge, Nicoline4 aut |
700 | 1 | a van Roozendaal, Kees E. P.4 aut |
700 | 1 | a Piedmonte, Marion4 aut |
700 | 1 | a Rubinstein, Wendy4 aut |
700 | 1 | a Nerenstone, Stacy4 aut |
700 | 1 | a Van Le, Linda4 aut |
700 | 1 | a Blank, Stephanie V.4 aut |
700 | 1 | a Caldes, Trinidad4 aut |
700 | 1 | a de la Hoya, Miguel4 aut |
700 | 1 | a Nevanlinna, Heli4 aut |
700 | 1 | a Aittomaki, Kristiina4 aut |
700 | 1 | a Lazaro, Conxi4 aut |
700 | 1 | a Blanco, Ignacio4 aut |
700 | 1 | a Arason, Adalgeir4 aut |
700 | 1 | a Johannsson, Oskar T.4 aut |
700 | 1 | a Barkardottir, Rosa B.4 aut |
700 | 1 | a Devilee, Peter4 aut |
700 | 1 | a Olopade, Olofunmilayo I.4 aut |
700 | 1 | a Neuhausen, Susan L.4 aut |
700 | 1 | a Wang, Xianshu4 aut |
700 | 1 | a Fredericksen, Zachary S.4 aut |
700 | 1 | a Peterlongo, Paolo4 aut |
700 | 1 | a Manoukian, Siranoush4 aut |
700 | 1 | a Barile, Monica4 aut |
700 | 1 | a Viel, Alessandra4 aut |
700 | 1 | a Radice, Paolo4 aut |
700 | 1 | a Phelan, Catherine M.4 aut |
700 | 1 | a Narod, Steven4 aut |
700 | 1 | a Rennert, Gad4 aut |
700 | 1 | a Lejbkowicz, Flavio4 aut |
700 | 1 | a Flugelman, Anath4 aut |
700 | 1 | a Andrulis, Irene L.4 aut |
700 | 1 | a Glendon, Gord4 aut |
700 | 1 | a Ozcelik, Hilmi4 aut |
700 | 1 | a Toland, Amanda E.4 aut |
700 | 1 | a Montagna, Marco4 aut |
700 | 1 | a D'Andrea, Emma4 aut |
700 | 1 | a Friedman, Eitan4 aut |
700 | 1 | a Laitman, Yael4 aut |
700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo |
700 | 1 | a Beattie, Mary4 aut |
700 | 1 | a Ramus, Susan J.4 aut |
700 | 1 | a Domchek, Susan M.4 aut |
700 | 1 | a Nathanson, Katherine L.4 aut |
700 | 1 | a Rebbeck, Tim4 aut |
700 | 1 | a Spurdle, Amanda B.4 aut |
700 | 1 | a Chen, Xiaoqing4 aut |
700 | 1 | a Holland, Helene4 aut |
700 | 1 | a John, Esther M.4 aut |
700 | 1 | a Hopper, John L.4 aut |
700 | 1 | a Buys, Saundra S.4 aut |
700 | 1 | a Daly, Mary B.4 aut |
700 | 1 | a Southey, Melissa C.4 aut |
700 | 1 | a Terry, Mary Beth4 aut |
700 | 1 | a Tung, Nadine4 aut |
700 | 1 | a Hansen, Thomas V. Overeem4 aut |
700 | 1 | a Nielsen, Finn C.4 aut |
700 | 1 | a Greene, Mark I.4 aut |
700 | 1 | a Mai, Phuong L.4 aut |
700 | 1 | a Osorio, Ana4 aut |
700 | 1 | a Duran, Mercedes4 aut |
700 | 1 | a Andres, Raquel4 aut |
700 | 1 | a Benitez, Javier4 aut |
700 | 1 | a Weitzel, Jeffrey N.4 aut |
700 | 1 | a Garber, Judy4 aut |
700 | 1 | a Hamann, Ute4 aut |
700 | 1 | a Peock, Susan4 aut |
700 | 1 | a Cook, Margaret4 aut |
700 | 1 | a Oliver, Clare4 aut |
700 | 1 | a Frost, Debra4 aut |
700 | 1 | a Platte, Radka4 aut |
700 | 1 | a Evans, D. Gareth4 aut |
700 | 1 | a Lalloo, Fiona4 aut |
700 | 1 | a Eeles, Ros4 aut |
700 | 1 | a Izatt, Louise4 aut |
700 | 1 | a Walker, Lisa4 aut |
700 | 1 | a Eason, Jacqueline4 aut |
700 | 1 | a Barwell, Julian4 aut |
700 | 1 | a Godwin, Andrew K.4 aut |
700 | 1 | a Schmutzler, Rita K.4 aut |
700 | 1 | a Wappenschmidt, Barbara4 aut |
700 | 1 | a Engert, Stefanie4 aut |
700 | 1 | a Arnold, Norbert4 aut |
700 | 1 | a Gadzicki, Dorothea4 aut |
700 | 1 | a Dean, Michael4 aut |
700 | 1 | a Gold, Bert4 aut |
700 | 1 | a Klein, Robert J.4 aut |
700 | 1 | a Couch, Fergus J.4 aut |
700 | 1 | a Chenevix-Trench, Georgia4 aut |
700 | 1 | a Easton, Douglas F.4 aut |
700 | 1 | a Daly, Mark J.4 aut |
700 | 1 | a Antoniou, Antonis C.4 aut |
700 | 1 | a Altshuler, David M.4 aut |
700 | 1 | a Offit, Kenneth4 aut |
710 | 2 | a Bröstcancer-genetikb Sektion I4 org |
773 | 0 | t PLoS Geneticsd : Public Library of Science (PLoS)g 6:10q 6:10x 1553-7404 |
856 | 4 | u https://portal.research.lu.se/files/2262625/1762681.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1371/journal.pgen.1001183x freey FULLTEXT |
856 | 4 | u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001183&type=printable |
856 | 4 8 | u https://lup.lub.lu.se/record/1752861 |
856 | 4 8 | u https://doi.org/10.1371/journal.pgen.1001183 |
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