Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes

Salami, FalastinLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Lund Univ, Clin Res Ctr, Skåne Univ Hosp, Dept Clin Sci, Malmö, Sweden,TEDDY Study Group (författare)

Islet autoantibodies (IAs) precede the clinical onset of type 1 diabetes (T1D); however, the knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4- to 12-year-old children with increased genetic risk for T1D. This study tested whether CBCs were altered in 4- to 12-year-old children without (n = 376) or with one or several IAs against insulin, GAD65, or IA-2 (n = 72). CBC was analyzed during longitudinal follow-up in 448 Swedish children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A linear mixed-effects model was used to assess potential association between IA and CBC measurements over time. The white blood cell and neutrophil counts were reduced in children with IAs, primarily in boys. In contrast, girls had lower levels of hemoglobin and hematocrit. Positivity for multiple IAs showed the lowest counts in white blood cells and neutrophils in boys and red blood cells, hemoglobin, and hematocrit in girls. These associations were primarily observed in children with the HLA-DR3-DQ2/DR4-DQ8 genotype. We conclude that the reduction in neutrophils and red blood cells in children with multiple IAs and HLA-DR3-DQ2/DR4-DQ8 genotype may signal a sex-dependent islet autoimmunity detected in longitudinal CBCs.

Lee, Hye SeungUniversity of South Florida,Univ S Florida, Hlth Informat Inst, Dept Pediat, Tampa, FL USA,TEDDY Study Group (författare)
Freyhult, Eva,1979-Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,TEDDY Study Group(Swepub:uu)evfre192 (författare)
Elding Larsson, HelenaLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Lund Univ, Clin Res Ctr, Skåne Univ Hosp, Dept Clin Sci, Malmö, Sweden,TEDDY Study Group(Swepub:lu)pedi-hla (författare)
Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Lund Univ, Clin Res Ctr, Skåne Univ Hosp, Dept Clin Sci, Malmö, Sweden,TEDDY Study Group(Swepub:lu)endo-ale (författare)
Törn, CarinaLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Lund Univ, Clin Res Ctr, Skåne Univ Hosp, Dept Clin Sci, Malmö, Sweden,TEDDY Study Group(Swepub:lu)med-cto (författare)
Celiaki och diabetesForskargrupper vid Lunds universitet (creator_code:org_t)
TEDDY Study Group

Ingår i:Diabetes: American Diabetes Association67:11, s. 2329-23361939-327X0012-1797

Av författaren/redakt...: Salami, Falastin; Lee, Hye Seung; Freyhult, Eva, 1 ...; Elding Larsson, ...; Lernmark, Åke; Törn, Carina

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.