onr:"swepub:oai:lup.lub.lu.se:a9a969d0-fd0c-46f4-8863-821e7baa8f8a"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03951naa a2200361 4500 | |
| 001 | oai:lup.lub.lu.se:a9a969d0-fd0c-46f4-8863-821e7baa8f8a | |
| 003 | SwePub | |
| 008 | 160401s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/1680602 URI |
| 024 | 7 | a https://doi.org/10.1128/AAC.00081-072 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Sandrini, Michaelu Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science4 aut0 (Swepub:lu)cob-msa |
| 245 | 1 0 | a Deoxyribonucleoside kinases activate nucleoside antibiotics in severe pathogenic bacteria. |
| 264 | 1 | c 2007 |
| 520 | a Common bacterial pathogens are becoming progressively more resistant to traditional antibiotics, representing a major public-health crisis. Therefore, there is a need for a variety of antibiotics with alternative modes of action. In our study, several nucleoside analogs were tested against pathogenic staphylococci and streptococci. We show that pyrimidine-based nucleoside analogs, like 3'-azido-3'-deoxythymidine (AZT) and 2',2'-difluoro-2'deoxycytidine (gemcitabine), are specifically activated by the endogenous bacterial deoxyribonucleoside kinases, leading to cell death. Deoxyribonucleoside kinase-deficient Escherichia coli strains become highly susceptible to nucleoside analogs when they express recombinant kinases from Staphylococcus aureus or Streptococcus pyogenes. We further demonstrate that recombinant S. aureus deoxyadenosine kinase efficiently phosphorylates the anticancer drug gemcitabine in vitro and is therefore the key enzyme in the activation pathway. When adult mice were infected intraperitoneally with a fatal dose of S. pyogenes strain AP1 and afterwards received gemcitabine, they failed to develop a systemic infection. Nucleoside analogs may therefore represent a promising alternative for combating pathogenic bacteria. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
| 700 | 1 | a Shannon, Oonaghu Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-osn |
| 700 | 1 | a Clausen, Anders Ranegaardu Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science4 aut0 (Swepub:lu)cob-asc |
| 700 | 1 | a Björck, Larsu Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-lbj |
| 700 | 1 | a Piskur, Jureu Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science4 aut0 (Swepub:lu)cob-jpi |
| 710 | 2 | a Biologiska institutionenb Naturvetenskapliga fakulteten4 org |
| 773 | 0 | t Antimicrobial Agents and Chemotherapyg 51:8, s. 2726-2732q 51:8<2726-2732x 1098-6596 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17526755&dopt=Abstractx freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1128/AAC.00081-07x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/168060 |
| 856 | 4 8 | u https://doi.org/10.1128/AAC.00081-07 |
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