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Relationship between HMF intake and SMF formation in vivo : An animal and human study
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- Pastoriza de la Cueva, Silvia (författare)
- University of Granada
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- Álvarez, Juana (författare)
- University of Granada
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- Végvári, Ákos (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Montilla-Gómez, Javier (författare)
- University of Granada
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- Cruz-López, Olga (författare)
- University of Granada
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- Delgado-Andrade, Cristina (författare)
- CSIC - Estación Experimental del Zaidín (EEZ)
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- Rufián-Henares, José A. (författare)
- University of Granada
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(creator_code:org_t)
- 2016-12-20
- 2017
- Engelska.
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Ingår i: Molecular Nutrition and Food Research. - : Wiley. - 1613-4125. ; 61:3
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Scope: 5-Hydroxymethylfurfural (HMF) is a furanic compound produced in heat-processed foods by nonenzymatic browning reactions. HMF has been demonstrated to be hepato- and nephrotoxic in animals with a link to its metabolite 5-sulfooxymethylfurfural (SMF). To date little is known about either the formation of SMF from ingested HMF or the formation of DNA adducts in animals or human beings. Methods and results: To assess SMF in vivo formation, we first performed a study in mice treated with high/low doses of oral HMF. We found increased concentrations of SMF in plasma and DNA SMF-adducts in leukocytes, hepatic tissue, and kidneys by means of LC-MS/MS, but no spatial formation in such tissues was observed by MALDI-MS imaging technology due to low sensitivity. In a second experiment, we measured the exposure to HMF in a Spanish preadolescent population. We analyzed the concentration of HMF metabolites (plasma, urine) and measured, for the first time, the presence of SMF in plasma and DNA SMF-adducts in leukocytes. Conclusion: This study provides the first evidence that oral HMF is readily transformed into SMF in vivo, giving rise to the formation of DNA adducts in a direct relation with HMF intake, both in animals and human beings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- 5-Hydroxymethylfurfural
- 5-Sulfooxymethylfurfural
- Estimated intake
- Heat processing
- Maillard reaction
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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