Sökning: onr:"swepub:oai:lup.lub.lu.se:ab111aca-769a-4d9f-92c5-9231ec557d24" > Leveraging cross-sp...
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000 | 05350naa a2200793 4500 | |
001 | oai:lup.lub.lu.se:ab111aca-769a-4d9f-92c5-9231ec557d24 | |
003 | SwePub | |
008 | 160401s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:128111323 | |
024 | 7 | a https://lup.lub.lu.se/record/42911442 URI |
024 | 7 | a https://doi.org/10.1016/j.cell.2013.10.0582 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1281113232 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Claussnitzer, Melina4 aut |
245 | 1 0 | a Leveraging cross-species transcription factor binding site patterns: from diabetes risk Loci to disease mechanisms. |
264 | 1 | b Elsevier BV,c 2014 |
338 | a electronic2 rdacarrier | |
520 | a Genome-wide association studies have revealed numerous risk loci associated with diverse diseases. However, identification of disease-causing variants within association loci remains a major challenge. Divergence in gene expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility. We show that integrative computational analysis of phylogenetic conservation with a complexity assessment of co-occurring transcription factor binding sites (TFBS) can identify cis-regulatory variants and elucidate their mechanistic role in disease. Analysis of established type 2 diabetes risk loci revealed a striking clustering of distinct homeobox TFBS. We identified the PRRX1 homeobox factor as a repressor of PPARG2 expression in adipose cells and demonstrate its adverse effect on lipid metabolism and systemic insulin sensitivity, dependent on the rs4684847 risk allele that triggers PRRX1 binding. Thus, cross-species conservation analysis at the level of co-occurring TFBS provides a valuable contribution to the translation of genetic association signals to disease-related molecular mechanisms. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Dankel, Simon N4 aut |
700 | 1 | a Klocke, Bernward4 aut |
700 | 1 | a Grallert, Harald4 aut |
700 | 1 | a Glunk, Viktoria4 aut |
700 | 1 | a Berulava, Tea4 aut |
700 | 1 | a Lee, Heekyoung4 aut |
700 | 1 | a Oskolkov, Nikolayu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-nao |
700 | 1 | a Fadista, Joaou Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-jft |
700 | 1 | a Ehlers, Kerstin4 aut |
700 | 1 | a Wahl, Simone4 aut |
700 | 1 | a Hoffmann, Christoph4 aut |
700 | 1 | a Qian, Kun4 aut |
700 | 1 | a Rönn, Tinau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics4 aut0 (Swepub:lu)med-tar |
700 | 1 | a Riess, Helene4 aut |
700 | 1 | a Müller-Nurasyid, Martina4 aut |
700 | 1 | a Bretschneider, Nancy4 aut |
700 | 1 | a Schroeder, Timm4 aut |
700 | 1 | a Skurk, Thomas4 aut |
700 | 1 | a Horsthemke, Bernhard4 aut |
700 | 1 | a Spieler, Derek4 aut |
700 | 1 | a Klingenspor, Martin4 aut |
700 | 1 | a Seifert, Martin4 aut |
700 | 1 | a Kern, Michael J4 aut |
700 | 1 | a Mejhert, Niklasu Karolinska Institutet4 aut |
700 | 1 | a Dahlman, Ingridu Karolinska Institutet4 aut |
700 | 1 | a Hansson, Olau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)medk-oha |
700 | 1 | a Hauck, Stefanie M4 aut |
700 | 1 | a Blüher, Matthias4 aut |
700 | 1 | a Arner, Peteru Karolinska Institutet4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Suhre, Karsten4 aut |
700 | 1 | a Hsu, Yi-Hsiang4 aut |
700 | 1 | a Mellgren, Gunnar4 aut |
700 | 1 | a Hauner, Hans4 aut |
700 | 1 | a Laumen, Helmut4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Celld : Elsevier BVg 156:1-2, s. 343-358q 156:1-2<343-358x 1097-4172x 0092-8674 |
856 | 4 | u https://portal.research.lu.se/files/1712826/4589438.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/24439387?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1016/j.cell.2013.10.058y FULLTEXT |
856 | 4 | u http://www.cell.com/article/S0092867413015353/pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/4291144 |
856 | 4 8 | u https://doi.org/10.1016/j.cell.2013.10.058 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:128111323 |
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