A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer

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Fältnamn	Indikatorer	Metadata
000		08001naa a2201885 4500
001		oai:lup.lub.lu.se:ab2c0c7b-2a25-495f-98ed-29e450e8d695
003		SwePub
008		160401s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:123716358
024	7	a https://lup.lub.lu.se/record/22790802 URI
024	7	a https://doi.org/10.1038/ng.9852 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1237163582 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Haiman, Christopher A.4 aut
245	1 0	a A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
264		c 2011-10-30
264	1	b Springer Science and Business Media LLC,c 2011
520		a Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 x 10(-10)). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 x 10(-9)), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 x 10(-9)). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
700	1	a Chen, Gary K.4 aut
700	1	a Vachon, Celine M.4 aut
700	1	a Canzian, Federico4 aut
700	1	a Dunning, Alison4 aut
700	1	a Millikan, Robert C.4 aut
700	1	a Wang, Xianshu4 aut
700	1	a Ademuyiwa, Foluso4 aut
700	1	a Ahmed, Shahana4 aut
700	1	a Ambrosone, Christine B.4 aut
700	1	a Baglietto, Laura4 aut
700	1	a Balleine, Rosemary4 aut
700	1	a Bandera, Elisa V.4 aut
700	1	a Beckmann, Matthias W.4 aut
700	1	a Berg, Christine D.4 aut
700	1	a Bernstein, Leslie4 aut
700	1	a Blomqvist, Carl4 aut
700	1	a Blot, William J.4 aut
700	1	a Brauch, Hiltrud4 aut
700	1	a Buring, Julie E.4 aut
700	1	a Carey, Lisa A.4 aut
700	1	a Carpenter, Jane E.4 aut
700	1	a Chang-Claude, Jenny4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Chasman, Daniel I.4 aut
700	1	a Clarke, Christine L.4 aut
700	1	a Cox, Angela4 aut
700	1	a Cross, Simon S.4 aut
700	1	a Deming, Sandra L.4 aut
700	1	a Diasio, Robert B.4 aut
700	1	a Dimopoulos, Athanasios M.4 aut
700	1	a Driver, W. Ryan4 aut
700	1	a Duennebier, Thomas4 aut
700	1	a Durcan, Lorraine4 aut
700	1	a Eccles, Diana4 aut
700	1	a Edlund, Christopher K.4 aut
700	1	a Ekici, Arif B.4 aut
700	1	a Fasching, Peter A.4 aut
700	1	a Feigelson, Heather S.4 aut
700	1	a Flesch-Janys, Dieter4 aut
700	1	a Fostira, Florentia4 aut
700	1	a Försti, Astau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-asf
700	1	a Fountzilas, George4 aut
700	1	a Gerty, Susan M.u Karolinska Institutet4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Godwin, Andrew K.4 aut
700	1	a Goodfellow, Paul4 aut
700	1	a Graham, Nikki4 aut
700	1	a Greco, Dario4 aut
700	1	a Hamann, Ute4 aut
700	1	a Hankinson, Susan E.4 aut
700	1	a Hartmann, Arndt4 aut
700	1	a Hein, Rebecca4 aut
700	1	a Heinz, Judith4 aut
700	1	a Holbrook, Andrea4 aut
700	1	a Hoover, Robert N.4 aut
700	1	a Hu, Jennifer J.4 aut
700	1	a Hunter, David J.4 aut
700	1	a Ingles, Sue A.4 aut
700	1	a Irwanto, Astrid4 aut
700	1	a Ivanovich, Jennifer4 aut
700	1	a John, Esther M.4 aut
700	1	a Johnson, Nicola4 aut
700	1	a Jukkola-Vuorinen, Arja4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Ko, Yon-Dschun4 aut
700	1	a Kolonel, Laurence N.4 aut
700	1	a Konstantopoulou, Irene4 aut
700	1	a Kosma, Veli-Matti4 aut
700	1	a Kulkarni, Swati4 aut
700	1	a Lambrechts, Diether4 aut
700	1	a Lee, Adam M.4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Lesnick, Timothy4 aut
700	1	a Liu, Jianjun4 aut
700	1	a Lindstrom, Sara4 aut
700	1	a Mannermaa, Arto4 aut
700	1	a Margolin, Sara4 aut
700	1	a Martin, Nicholas G.4 aut
700	1	a Miron, Penelope4 aut
700	1	a Montgomery, Grant W.4 aut
700	1	a Nevanlinna, Heli4 aut
700	1	a Nickels, Stephan4 aut
700	1	a Nyante, Sarah4 aut
700	1	a Olswold, Curtis4 aut
700	1	a Palmer, Julie4 aut
700	1	a Pathak, Harsh4 aut
700	1	a Pectasides, Dimitrios4 aut
700	1	a Perou, Charles M.4 aut
700	1	a Peto, Julian4 aut
700	1	a Pharoah, Paul D. P.4 aut
700	1	a Pooler, Loreall C.4 aut
700	1	a Press, Michael F.4 aut
700	1	a Pylkas, Katri4 aut
700	1	a Rebbeck, Timothy R.4 aut
700	1	a Rodriguez-Gil, Jorge L.4 aut
700	1	a Rosenberg, Lynn4 aut
700	1	a Ross, Eric4 aut
700	1	a Ruediger, Thomas4 aut
700	1	a Silva, Isabel dos Santos4 aut
700	1	a Sawyer, Elinor4 aut
700	1	a Schmidt, Marjanka K.4 aut
700	1	a Schulz-Wendtland, Ruediger4 aut
700	1	a Schumacher, Fredrick4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Sheng, Xin4 aut
700	1	a Signorello, Lisa B.4 aut
700	1	a Sinn, Hans-Peter4 aut
700	1	a Stevens, Kristen N.4 aut
700	1	a Southey, Melissa C.4 aut
700	1	a Tapper, William J.4 aut
700	1	a Tomlinson, Ian4 aut
700	1	a Hogervorst, Frans B. L.4 aut
700	1	a Wauters, Els4 aut
700	1	a Weaver, JoEllen4 aut
700	1	a Wildiers, Hans4 aut
700	1	a Winqvist, Robert4 aut
700	1	a Van Den Berg, David4 aut
700	1	a Wan, Peggy4 aut
700	1	a Xia, Lucy Y.4 aut
700	1	a Yannoukakos, Drakoulis4 aut
700	1	a Zheng, Wei4 aut
700	1	a Ziegler, Regina G.4 aut
700	1	a Siddiq, Afshan4 aut
700	1	a Slager, Susan L.4 aut
700	1	a Stram, Daniel O.4 aut
700	1	a Easton, Douglas4 aut
700	1	a Kraft, Peter4 aut
700	1	a Henderson, Brian E.4 aut
700	1	a Couch, Fergus J.4 aut
710	2	a Allmänmedicin och klinisk epidemiologib Forskargrupper vid Lunds universitet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 43:12, s. 61-1210q 43:12<61-1210x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.985y FULLTEXT
856	4	u https://cdr.lib.unc.edu/downloads/5h73q3512
856	4 8	u https://lup.lub.lu.se/record/2279080
856	4 8	u https://doi.org/10.1038/ng.985
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:123716358

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Av författaren/redakt...: Haiman, Christop ...; Chen, Gary K.; Vachon, Celine M ...; Canzian, Federic ...; Dunning, Alison; Millikan, Robert ...; visa fler...; Wang, Xianshu; Ademuyiwa, Folus ...; Ahmed, Shahana; Ambrosone, Chris ...; Baglietto, Laura; Balleine, Rosema ...; Bandera, Elisa V ...; Beckmann, Matthi ...; Berg, Christine ...; Bernstein, Lesli ...; Blomqvist, Carl; Blot, William J.; Brauch, Hiltrud; Buring, Julie E.; Carey, Lisa A.; Carpenter, Jane ...; Chang-Claude, Je ...; Chanock, Stephen ...; Chasman, Daniel ...; Clarke, Christin ...; Cox, Angela; Cross, Simon S.; Deming, Sandra L ...; Diasio, Robert B ...; Dimopoulos, Atha ...; Driver, W. Ryan; Duennebier, Thom ...; Durcan, Lorraine; Eccles, Diana; Edlund, Christop ...; Ekici, Arif B.; Fasching, Peter ...; Feigelson, Heath ...; Flesch-Janys, Di ...; Fostira, Florent ...; Försti, Asta; Fountzilas, Geor ...; Gerty, Susan M.; Giles, Graham G.; Godwin, Andrew K ...; Goodfellow, Paul; Graham, Nikki; Greco, Dario; Hamann, Ute; Hankinson, Susan ...; Hartmann, Arndt; Hein, Rebecca; Heinz, Judith; Holbrook, Andrea; Hoover, Robert N ...; Hu, Jennifer J.; Hunter, David J.; Ingles, Sue A.; Irwanto, Astrid; Ivanovich, Jenni ...; John, Esther M.; Johnson, Nicola; Jukkola-Vuorinen ...; Kaaks, Rudolf; Ko, Yon-Dschun; Kolonel, Laurenc ...; Konstantopoulou, ...; Kosma, Veli-Matt ...; Kulkarni, Swati; Lambrechts, Diet ...; Lee, Adam M.; Le Marchand, Loi ...; Lesnick, Timothy; Liu, Jianjun; Lindstrom, Sara; Mannermaa, Arto; Margolin, Sara; Martin, Nicholas ...; Miron, Penelope; Montgomery, Gran ...; Nevanlinna, Heli; Nickels, Stephan; Nyante, Sarah; Olswold, Curtis; Palmer, Julie; Pathak, Harsh; Pectasides, Dimi ...; Perou, Charles M ...; Peto, Julian; Pharoah, Paul D. ...; Pooler, Loreall ...; Press, Michael F ...; Pylkas, Katri; Rebbeck, Timothy ...; Rodriguez-Gil, J ...; Rosenberg, Lynn; Ross, Eric; Ruediger, Thomas; Silva, Isabel do ...; Sawyer, Elinor; Schmidt, Marjank ...; Schulz-Wendtland ...; Schumacher, Fred ...; Severi, Gianluca; Sheng, Xin; Signorello, Lisa ...; Sinn, Hans-Peter; Stevens, Kristen ...; Southey, Melissa ...; Tapper, William ...; Tomlinson, Ian; Hogervorst, Fran ...; Wauters, Els; Weaver, JoEllen; Wildiers, Hans; Winqvist, Robert; Van Den Berg, Da ...; Wan, Peggy; Xia, Lucy Y.; Yannoukakos, Dra ...; Zheng, Wei; Ziegler, Regina ...; Siddiq, Afshan; Slager, Susan L.; Stram, Daniel O.; Easton, Douglas; Kraft, Peter; Henderson, Brian ...; Couch, Fergus J.; visa färre...

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