Sökning: onr:"swepub:oai:lup.lub.lu.se:ad09ed5b-6caf-4623-831b-66f35d900da0" >
Host tropism determ...
Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system
-
- Hart, Thomas M. (författare)
- Wadsworth Center for Laboratories and Research,University at Albany, SUNY
-
- Dupuis, Alan P. (författare)
- Wadsworth Center for Laboratories and Research
-
- Tufts, Danielle M. (författare)
- Columbia University
-
visa fler...
-
- Blom, Anna M. (författare)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups
-
- Starkey, Simon R. (författare)
- Wadsworth Center for Laboratories and Research
-
- Rego, Ryan O.M. (författare)
- Institute of Parasitology, Czech Academy of Sciences,University of South Bohemia
-
- Ram, Sanjay (författare)
- University of Massachusetts Medical School
-
- Kraiczy, Peter (författare)
- University Hospital Frankfurt
-
- Kramer, Laura D. (författare)
- Wadsworth Center for Laboratories and Research,University at Albany, SUNY
-
- Diuk-Wasser, Maria A. (författare)
- Columbia University
-
- Kolokotronis, Sergios Orestis (författare)
- SUNY Downstate Health Sciences University
-
- Lin, Yi Pin (författare)
- University at Albany, SUNY,Wadsworth Center for Laboratories and Research
-
visa färre...
-
(creator_code:org_t)
- 2021-07-29
- 2021
- Engelska.
-
Ingår i: PLoS Pathogens. - : Public Library of Science (PLoS). - 1553-7366 .- 1553-7374. ; 17:7
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://journals.plo...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Pathogens possess the ability to adapt and survive in some host species but not in others–an ecological trait known as host tropism. Transmitted through ticks and carried mainly by mammals and birds, the Lyme disease (LD) bacterium is a well-suited model to study such tropism. Three main causative agents of LD, Borrelia burgdorferi, B. afzelii, and B. garinii, vary in host ranges through mechanisms eluding characterization. By feeding ticks infected with different Borrelia species, utilizing feeding chambers and live mice and quail, we found species-level differences in bacterial transmission. These differences localize on the tick blood meal, and specifically complement, a defense in vertebrate blood, and a polymorphic bacterial protein, CspA, which inactivates complement by binding to a host complement inhibitor, Factor H (FH). CspA selectively confers bacterial transmission to vertebrates that produce FH capable of allele-specific recognition. CspA is the only member of the Pfam54 gene family to exhibit host-specific FH-binding. Phylogenetic analyses revealed convergent evolution as the driver of such uniqueness, and that FH-binding likely emerged during the last glacial maximum. Our results identify a determinant of host tropism in Lyme disease infection, thus defining an evolutionary mechanism that shapes host-pathogen associations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hart, Thomas M.
-
Dupuis, Alan P.
-
Tufts, Danielle ...
-
Blom, Anna M.
-
Starkey, Simon R ...
-
Rego, Ryan O.M.
-
visa fler...
-
Ram, Sanjay
-
Kraiczy, Peter
-
Kramer, Laura D.
-
Diuk-Wasser, Mar ...
-
Kolokotronis, Se ...
-
Lin, Yi Pin
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Infektionsmedici ...
- Artiklar i publikationen
-
PLoS Pathogens
- Av lärosätet
-
Lunds universitet