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Semen quality in re...
Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations
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- Toft, Gunnar (författare)
- Aarhus University Hospital
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- Long, Manhai (författare)
- Aarhus University
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- Krüger, Tanja (författare)
- Aarhus University
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- Hjelmborg, Philip S. (författare)
- Aarhus University
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- Bonde, Jens Peter (författare)
- Aarhus University Hospital
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- Rignell-Hydbom, Anna (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Miljöepidemiologi,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Environmental Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Tyrkiel, Ewa (författare)
- National Institute of Public Health-National Institute of Hygiene, Poland
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- Hagmar, Lars (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Giwercman, Aleksander (författare)
- Skåne University Hospital
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- Spanó, Marcello (författare)
- ENEA Casaccia Research Center, Rome
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- Bizzaro, Davide (författare)
- Marche Polytechnic University
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- Pedersen, Henning S. (författare)
- Centre for Arctic Environmental Medicine
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- Lesovoy, Vladymir (författare)
- Kharkiv Regional Clinical Centre of Urology and Nephrology
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- Ludwicki, Jan K. (författare)
- National Institute of Public Health-National Institute of Hygiene, Poland
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- Bonefeld-Jørgensen, Eva C. (författare)
- Aarhus University
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(creator_code:org_t)
- Environmental Health Perspectives, 2007
- 2007
- Engelska 6 s.
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Ingår i: Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 115:SUPPL1, s. 15-20
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in raw lipophilic serum extracts free of proteins. RESULTS: All together, 319 men from Warsaw (Poland), Greenland, Kharkiv (Ukraine), and Sweden provided semen and blood samples. No strong and consistent associations between xenobiotic activity and semen quality measures were observed in the four populations. However, when the data were combined across populations sperm concentration increased 40% per unit increase in XER activity [95% confidence interval (CI), 1-79%] in the subgroup with XER activity below the reference level. Among subjects with XER activity above the reference level an increase of 14% (95% CI, 2-28%) was found. Furthermore, an increase of 10% motile sperm per unit increase in XER activity below reference level (95% CI, 0.2-20) was found. We are unable to exclude that the associations are chance findings. CONCLUSION: Alteration of XER, XAR, or AhR transactivity within the range found in serum from the general European and Inuit population seems not to markedly deteriorate sperm cell concentration, motility, or morphology in adult men.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Androgen receptor
- Aryl hydrocarbon receptor
- Calux
- Endocrine disruption
- Estrogen receptor
- Human
- Sperm
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Toft, Gunnar
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Long, Manhai
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Krüger, Tanja
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Hjelmborg, Phili ...
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Bonde, Jens Pete ...
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Rignell-Hydbom, ...
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visa fler...
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Tyrkiel, Ewa
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Hagmar, Lars
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Giwercman, Aleks ...
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Spanó, Marcello
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Bizzaro, Davide
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Pedersen, Hennin ...
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Lesovoy, Vladymi ...
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Ludwicki, Jan K.
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Bonefeld-Jørgens ...
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