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Iohexol plasma clea...
Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research : A review. Part 2: Why to measure glomerular filtration rate with iohexol?
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- Delanaye, Pierre (författare)
- University of Liège Hospital
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- Melsom, Toralf (författare)
- UiT The Arctic University of Norway, Tromsø
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- Ebert, Natalie (författare)
- Charité - University Medicine Berlin
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- Bäck, Sten Erik (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Mariat, Christophe (författare)
- Jean Monnet University
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- Cavalier, Etienne (författare)
- University of Liège Hospital
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- Björk, Jonas (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Christensson, Anders (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Nyman, Ulf (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital
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- Porrini, Esteban (författare)
- University of La Laguna (ULL)
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- Remuzzi, Giuseppe (författare)
- Mario Negri Institute for Pharmacological Research
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- Ruggenenti, Piero (författare)
- Mario Negri Institute for Pharmacological Research
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- Schaeffner, Elke (författare)
- Charité - University Medicine Berlin
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- Soveri, Inga, 1978- (författare)
- Uppsala universitet,Uppsala University,Njurmedicin,Renal Medicine
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- Sterner, Gunnar (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Eriksen, Bjørn Odvar (författare)
- UiT The Arctic University of Norway, Tromsø
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- Gaspari, Flavio (författare)
- Mario Negri Institute for Pharmacological Research
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(creator_code:org_t)
- 2016-09-09
- 2016
- Engelska 5 s.
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Ingår i: Clinical Kidney Journal. - : Oxford University Press (OUP). - 2048-8505 .- 2048-8513. ; 9:5, s. 700-704
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://academic.oup...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the only valuable test to confirm or confute the status of chronic kidney disease (CKD), to evaluate the slope of renal function decay over time, to assess the suitability of living kidney donors and for dosing of potentially toxic medication with a narrowtherapeutic index. Abnormally elevated GFR or hyperfiltration in patients with diabetes or obesity can be correctly diagnosed only by measuring GFR. GFR measurement contributes to assessing the true CKD prevalence rate, avoiding discrepancies due to GFR estimation with different equations. Using measured GFR, successfully accomplished in large epidemiological studies, is the onlyway to study the potential link between decreased renal function and cardiovascular or total mortality, being sure that this association is not due to confounders, i.e. non-GFR determinants of biomarkers. In clinical research, it has been shown that measured GFR (or measured GFR slope) as a secondary endpoint as compared with estimated GFR detected subtle treatment effects and obtained these results with a comparatively smaller sample size than trials choosing estimated GFR. Measuring GFR by iohexol has several advantages: simplicity, low cost, stability and low interlaboratory variation. Iohexol plasma clearance represents the best chance for implementing a standardized GFR measurement protocol applicable worldwide both in clinical practice and in research.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Glomerular filtration rate
- Iohexol
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Delanaye, Pierre
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Melsom, Toralf
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Ebert, Natalie
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Bäck, Sten Erik
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Mariat, Christop ...
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Cavalier, Etienn ...
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Björk, Jonas
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Christensson, An ...
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Nyman, Ulf
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Porrini, Esteban
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Remuzzi, Giusepp ...
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Ruggenenti, Pier ...
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Schaeffner, Elke
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Soveri, Inga, 19 ...
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Sterner, Gunnar
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Eriksen, Bjørn O ...
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Gaspari, Flavio
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Clinical Kidney ...
- Av lärosätet
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Lunds universitet
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Uppsala universitet