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A Screening Tool to...
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Koens, Lisette HUniversity of Groningen
(författare)
A Screening Tool to Quickly Identify Movement Disorders in Patients with Inborn Errors of Metabolism
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:af0c5322-b9c0-43f4-8470-de1a0e0562da
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https://lup.lub.lu.se/record/af0c5322-b9c0-43f4-8470-de1a0e0562daURI
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https://doi.org/10.1002/mds.29332DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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BACKGROUND: Movement disorders are frequent in patients with inborn errors of metabolism (IEMs) but poorly recognized, particularly by nonmovement disorder specialists. We propose an easy-to-use clinical screening tool to help recognize movement disorders.OBJECTIVE: The aim is to develop a user-friendly rapid screening tool for nonmovement disorder specialists to detect moderate and severe movement disorders in patients aged ≥4 years with IEMs.METHODS: Videos of 55 patients with different IEMs were scored by experienced movement disorder specialists (n = 12). Inter-rater agreements were determined on the presence and subtype of the movement disorder. Based on ranking and consensus, items were chosen to be incorporated into the screening tool.RESULTS: A movement disorder was rated as present in 80% of the patients, with a moderate inter-rater agreement (κ =0.420, P < 0.001) on the presence of a movement disorder. When considering only moderate and severe movement disorders, the inter-rater agreement increased to almost perfect (κ = 0.900, P < 0.001). Dystonia was most frequently scored (27.3%) as the dominant phenotype. Treatment was mainly suggested for patients with moderate or severe movement disorders. Walking, observations of the arms, and drawing a spiral were found to be the most informative tasks and were included in the screening tool.CONCLUSIONS: We designed a screening tool to recognize movement disorders in patients with IEMs. We propose that this screening tool can contribute to select patients who should be referred to a movement disorder specialist for further evaluation and, if necessary, treatment of the movement disorder. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Klamer, Marrit RUniversity of Groningen
(författare)
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Sival, Deborah AUniversity Medical Center Groningen
(författare)
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Balint, BettinaUniversity of Zurich
(författare)
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Bhatia, Kailash PUniversity College London
(författare)
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Contarino, Maria FiorellaHaga Teaching Hospital
(författare)
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van Egmond, Martje EUniversity Medical Center Groningen
(författare)
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Erro, RobertoUniversity of Salerno
(författare)
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Friedman, JenniferRady Children’s Institute for Genomic Medicine
(författare)
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Fung, Victor S CUniversity of Sydney
(författare)
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Ganos, Christos
(författare)
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Kurian, Manju A
(författare)
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Lang, Anthony E
(författare)
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McGovern, Eavan M
(författare)
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Roze, Emmanuel
(författare)
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de Koning, Tom JLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University Medical Center Groningen,University of Groningen(Swepub:lu)to2856jd
(författare)
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Tijssen, Marina A J
(författare)
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University of GroningenUniversity Medical Center Groningen
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Movement Disorders: Wiley38:4, s. 646-6530885-31851531-8257
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- Av författaren/redakt...
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Koens, Lisette H
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Klamer, Marrit R
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Sival, Deborah A
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Balint, Bettina
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Bhatia, Kailash ...
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Contarino, Maria ...
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visa fler...
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van Egmond, Mart ...
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Erro, Roberto
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Friedman, Jennif ...
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Fung, Victor S C
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Ganos, Christos
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Kurian, Manju A
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Lang, Anthony E
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McGovern, Eavan ...
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Roze, Emmanuel
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de Koning, Tom J
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Tijssen, Marina ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Movement Disorde ...
- Av lärosätet
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Lunds universitet