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IL-23R deficiency d...
IL-23R deficiency does not impact atherosclerotic plaque development in mice
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- Engelbertsen, Daniel (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Depuydt, Marie A.C. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
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- Verwilligen, Robin A.F. (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Rattik, Sara (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Levinsohn, Erik (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Edsfeldt, Andreas (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Kuperwaser, Felicia (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
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- Jarolim, Petr (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Lichtman, Andrew H. (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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(creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 7:8
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background--Interleukin-23 (IL-23) has been implicated in inflammatory and autoimmune diseases by skewing CD4+ T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of IL-23 receptor (IL-23R)-expressing cells in the atherosclerotic aorta and evaluated the effect of IL-23R deficiency on atherosclerosis development in mice. Methods and Results--We used heterozygous Ldlr-/-Il23reGFP/WT knock-in mice to identify IL-23R-expressing cells by flow cytometry and homozygous Ldlr-/-Il23reGFP/eGFP (Ldlr-/- Il23r-/-) mice to investigate the effect of lack of IL-23R in atherosclerosis. We demonstrate the presence of relatively rare IL-23R-expressing cells in lymphoid tissue and aorta (≈0.1-1% IL23R+ cells of all CD45+ leukocytes). After 10 weeks on a high-fat diet, production of IL-17, but not interferon-c, by CD4+ T cells and other lymphocytes was reduced in Ldlr-/- Il23r-/- compared with Ldlr-/-controls. However, Ldlr-/- and Ldlr-/-Il23r-/- mice had equivalent amounts of aortic sinus and descending aorta lesions. Adoptive transfer of IL-23R-deficient CD4+ T cells to lymphopenic Ldlr-/-Rag1-/- resulted in dramatically reduced IL-17-producing T cells but did not reduce atherosclerosis, compared with transfer of IL-23R-sufficient CD4+ T cells. Conclusions--These data demonstrate that loss of IL-23R does not affect development of experimental atherosclerosis in LDLrdeficient mice, despite a role for IL-23 in differentiation of IL-17-producing T cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Atherosclerosis
- IL-17
- IL-23R
- Lymphocyte
- Th17
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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