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Biweekly fluctuatio...
Biweekly fluctuations of neuropsychiatric symptoms according to the Neuropsychiatric Inventory : Erratic symptoms or scores?
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- Eikelboom, Willem S. (författare)
- Erasmus University Medical Center
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- den Teuling, Amy (författare)
- Erasmus University Medical Center
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- Pol, Daphne E. (författare)
- Erasmus University Medical Center
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- Coesmans, Michiel (författare)
- Erasmus University Medical Center
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- Franzen, Sanne (författare)
- Erasmus University Medical Center
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- Jiskoot, Lize C. (författare)
- Erasmus University Medical Center
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- van Hemmen, Judy (författare)
- Erasmus University Medical Center
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- Singleton, Ellen H. (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam
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- de Jong, Frank Jan (författare)
- Erasmus University Medical Center
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- van den Berg, Esther (författare)
- Erasmus University Medical Center
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- Papma, Janne M. (författare)
- Erasmus University Medical Center
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(creator_code:org_t)
- 2022-06-15
- 2022
- Engelska.
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Ingår i: International Journal of Geriatric Psychiatry. - : Wiley. - 0885-6230 .- 1099-1166. ; 37:7
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Abstract
Ämnesord
Stäng
- Objectives: This study investigates the stability of neuropsychiatric symptoms (NPS) assessed biweekly using the Neuropsychiatric Inventory (NPI) in a memory clinic population during a 6 week period. Methods: Twenty-three spousal caregivers (mean [SD] age = 69.7 [8.8], 82.6% female) of 23 patients (43.5% had dementia) completed all assessments. The NPI was assessed four times during 6 weeks. We examined whether NPI domains were present during all four assessments, studied within-person variation for each NPI domain, and calculated Spearman's correlations between subsequent time-points. Furthermore, we associated repeated NPI assessments with repeated measures of caregiver burden to examine the clinical impact of changes in NPI scores over time. Results: The course of NPS was highly irregular according to the NPI, with only 35.8% of the NPI domains that were present at baseline persisted during all 6 weeks. We observed large within-person variation in the presence of individual NPI domains (61.3%, range 37.5%–83.9%) and inconsistent correlations between NPI assessments (e.g., range rs = 0.20–0.57 for agitation, range rs = 0.29–0.59 for anxiety). Higher NPI total scores were related to higher caregiver burden (rs = 0.60, p < 0.001), but changes in NPI total scores were unrelated to changes in caregiver burden (rs = 0.16, p = 0.20). Conclusions: We observed strong fluctuations in NPI scores within very short time windows raising the question whether this represents erratic symptoms and/or scores. Further studies are needed to investigate the origins of these fluctuations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- Alzheimer's disease
- behavioral and psychological symptoms of dementia (BPSD)
- behavioral symptoms
- dementia
- Neuropsychiatric Inventory
- neuropsychiatric symptoms
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Eikelboom, Wille ...
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den Teuling, Amy
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Pol, Daphne E.
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Coesmans, Michie ...
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Franzen, Sanne
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Jiskoot, Lize C.
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visa fler...
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van Hemmen, Judy
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Singleton, Ellen ...
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Ossenkoppele, Ri ...
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de Jong, Frank J ...
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van den Berg, Es ...
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Papma, Janne M.
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