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Integrative pathway...
Integrative pathway enrichment analysis of multivariate omics data
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- Paczkowska, Marta (författare)
- Ontario Institute for Cancer Research
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- Barenboim, Jonathan (författare)
- Ontario Institute for Cancer Research
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- Sintupisut, Nardnisa (författare)
- Ontario Institute for Cancer Research
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- Fox, Natalie S (författare)
- University of Toronto
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- Zhu, Helen (författare)
- University of Toronto
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- Abd-Rabbo, Diala (författare)
- Ontario Institute for Cancer Research
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- Mee, Miles W (författare)
- Ontario Institute for Cancer Research
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- Boutros, Paul C (författare)
- University of Toronto
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- Reimand, Jüri (författare)
- University of Toronto
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- Borg, Åke (creator_code:cre_t)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Ringnér, Markus (creator_code:cre_t)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science
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- Staaf, Johan (creator_code:cre_t)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
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- 2020-02-05
- 2020
- Engelska 16 s.
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adenocarcinoma/genetics
- Apoptosis/genetics
- Breast Neoplasms/genetics
- Chromatin Immunoprecipitation
- Computational Biology/methods
- Databases, Factual
- Female
- Gene Dosage
- Gene Expression Profiling
- Gene Regulatory Networks
- Genomics/methods
- Hippo Signaling Pathway
- Humans
- Metabolic Networks and Pathways/genetics
- Mutation
- Neoplasms/genetics
- Prognosis
- Protein Serine-Threonine Kinases/genetics
- RNA, Messenger/genetics
- Sequence Analysis, RNA
- Signal Transduction
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Paczkowska, Mart ...
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Barenboim, Jonat ...
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Sintupisut, Nard ...
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Fox, Natalie S
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Zhu, Helen
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Abd-Rabbo, Diala
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visa fler...
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Mee, Miles W
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Boutros, Paul C
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Reimand, Jüri
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Borg, Åke
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Ringnér, Markus
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Staaf, Johan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Data och informa ...
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och Bioinformatik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Nature Communica ...
- Av lärosätet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet