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GBV-C/HGV infection...
GBV-C/HGV infection in hepatitis C virus-infected deferred Swedish blood donors
- Artikel/kapitelEngelska1998
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LIBRIS-ID:oai:lup.lub.lu.se:b6c11551-511b-4adb-a3bc-a502ebab965e
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https://lup.lub.lu.se/record/1112751URI
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https://doi.org/10.1002/(SICI)1096-9071(199802)54:2<75::AID-JMV1>3.0.CO;2-LDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1943921URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Sera from 62 hepatitis C virus (HCV)-infected Swedish blood donors were tested by a nested polymerase chain reaction using primers targeting the 5'-noncoding region of the GB virus-C/hepatitis G (GBV-C/HGV) genome and an enzyme-linked immunosorbent assay that detects antibodies to the envelope protein E2 of GBV-C/HGV (anti-E2). Fourteen (22%) and 21 (34%) of the 62 blood donors were found to be GBV-C/HGV RNA and anti-E2 positive, respectively. None of the blood donors was positive for both GBV-C/HGV RNA and anti-E2. Thus, 35 of 62 (56%) HCV-infected donors had been exposed to GBV-C/HGV infection. At sequencing of the 14 GBV-C/HGV isolates, 12 were identified as subtype 2a and 2 as subtype 2b. One of 7 (14%) donors with mild liver disease such as steatosis and nonspecific reactive hepatitis had been exposed to GBV-C/HGV vs. 34 of 55 (62%) with chronic hepatitis with or without cirrhosis (P = 0.04). All other differences in histology were small between HCV and dual HCV GBV-C/HGV-infected donors. In conclusion, more than half of HCV-infected Swedish blood donors in this study were positive for either GBV-C/HGV RNA or anti-E2. GBV-C/HGV viremia and seropositivity were mutually exclusive.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Björkman, PerLund University,Lunds universitet,Enheten för infektionssjukdomar,Forskargrupper vid Lunds universitet,Infectious Diseases Research Unit,Lund University Research Groups(Swepub:lu)inf-pbj
(författare)
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Norkrans, G
(författare)
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Foberg, U
(författare)
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Fryden, A
(författare)
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Lindh, GKarolinska Institutet
(författare)
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Lindholm, A
(författare)
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Weiland, OKarolinska Institutet
(författare)
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Widell, AndersLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mikr-awi
(författare)
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Enheten för infektionssjukdomarForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Medical Virology54:2, s. 75-791096-90710146-6615
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