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Sökning: onr:"swepub:oai:lup.lub.lu.se:b6c67cca-1207-4134-8c7b-0ca0c679e4db" > Transient Motion Cl...

Transient Motion Classification Through Turbid Volumes via Parallelized Single-Photon Detection and Deep Contrastive Embedding

Xu, Shiqi (författare)
Duke University
Liu, Wenhui (författare)
Tsinghua University,Duke University
Yang, Xi (författare)
Duke University
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Jönsson, Joakim (författare)
Lund University,Lunds universitet,Förbränningsfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Combustion Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH
Qian, Ruobing (författare)
Duke University
McKee, Paul (författare)
Duke University
Kim, Kanghyun (författare)
Duke University
Konda, Pavan Chandra (författare)
Duke University
Zhou, Kevin C. (författare)
Duke University
Kreiß, Lucas (författare)
Duke University,Friedrich-Alexander University Erlangen-Nürnberg
Wang, Haoqian (författare)
Tsinghua University
Berrocal, Edouard (författare)
Lund University,Lunds universitet,Förbränningsfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,LTH profilområde: Avancerade ljuskällor,LTH profilområden,LTH profilområde: Energiomställningen,Combustion Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Photon Science and Technology,LTH Profile areas,Faculty of Engineering, LTH,LTH Profile Area: The Energy Transition,Faculty of Engineering, LTH
Huettel, Scott A. (författare)
Duke University
Horstmeyer, Roarke (författare)
Duke University
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 (creator_code:org_t)
2022-07-08
2022
Engelska.
Ingår i: Frontiers in Neuroscience. - : Frontiers Media SA. - 1662-4548 .- 1662-453X. ; 16
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Fast noninvasive probing of spatially varying decorrelating events, such as cerebral blood flow beneath the human skull, is an essential task in various scientific and clinical settings. One of the primary optical techniques used is diffuse correlation spectroscopy (DCS), whose classical implementation uses a single or few single-photon detectors, resulting in poor spatial localization accuracy and relatively low temporal resolution. Here, we propose a technique termed Classifying Rapid decorrelation Events via Parallelized single photon dEtection (CREPE), a new form of DCS that can probe and classify different decorrelating movements hidden underneath turbid volume with high sensitivity using parallelized speckle detection from a 32 × 32 pixel SPAD array. We evaluate our setup by classifying different spatiotemporal-decorrelating patterns hidden beneath a 5 mm tissue-like phantom made with rapidly decorrelating dynamic scattering media. Twelve multi-mode fibers are used to collect scattered light from different positions on the surface of the tissue phantom. To validate our setup, we generate perturbed decorrelation patterns by both a digital micromirror device (DMD) modulated at multi-kilo-hertz rates, as well as a vessel phantom containing flowing fluid. Along with a deep contrastive learning algorithm that outperforms classic unsupervised learning methods, we demonstrate our approach can accurately detect and classify different transient decorrelation events (happening in 0.1–0.4 s) underneath turbid scattering media, without any data labeling. This has the potential to be applied to non-invasively monitor deep tissue motion patterns, for example identifying normal or abnormal cerebral blood flow events, at multi-Hertz rates within a compact and static detection probe.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Annan medicinteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Other Medical Engineering (hsv//eng)

Nyckelord

contrastive learning
diffuse correlation
multimode fiber
neurobehavior
self-supervised learning
SPAD array
zero-shot learning

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