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Lymphovascular spac...
Lymphovascular space invasion as a predictive factor for lymph node metastases and survival in endometrioid endometrial cancer - a Swedish Gynecologic Cancer Group (SweGCG) study
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- Stålberg, Karin (författare)
- Uppsala universitet,Uppsala University,Reproduktiv hälsa,Uppsala Univ, Sweden
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- Bjurberg, Maria (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Head and Neck Cancer Research Group,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp Lund, Dept Hematol Oncol & Radiat Phys, Lund, Sweden;Lund Univ, Dept Clin Sci, Lund, Sweden
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- Borgfeldt, Christer (författare)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Dept Clin Sci, Lund, Sweden;Skane Univ Hosp, Dept Obstet & Gynecol, Lund, Sweden
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- Carlson, Joseph (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Univ Hosp, Dept Pathol & Cytol, Stockholm, Sweden;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
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- Dahm-Kähler, Pernilla (författare)
- University of Gothenburg,Sahlgrenska Academy,Gothenburg Univ, Sahgrenska Univ Hosp, Sahlgrenska Acad, Dept Obstet & Gynecol, Gothenburg, Sweden
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- Flöter-Rådestad, Angelique (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Obstet & Gynecol, Stockholm, Sweden
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- Hellman, Kristina (författare)
- Karolinska University Hospital,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden;Karolinska Univ Hosp, Dept Oncol & Pathol, Stockholm, Sweden
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- Hjerpe, Elisabet (författare)
- Karolinska University Hospital,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden;Karolinska Univ Hosp, Dept Oncol & Pathol, Stockholm, Sweden
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- Holmberg, Erik (författare)
- Sahlgrenska Academy,Sahlgrens Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden;Sahlgrens Univ Hosp, Reg Canc Ctr Vast, Gothenburg, Sweden
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- Kjölhede, Preben (författare)
- Linköpings universitet,Linköping University,Linkoping Univ, Dept Obstet & Gynecol, Linkoping, Sweden;Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US
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- Marcickiewicz, Janusz (författare)
- Hallands sjukhus, Varberg,Regional Cancer Center Western Sweden,Reg Canc Ctr Vast, Gothenburg, Sweden;Hallands Hosp Varberg, Dept Obstet & Gynecol, Varberg, Sweden
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- Rosenberg, Per (författare)
- Linköpings universitet,Linköping University,Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden;Linkoping Univ, Dept Clin Oncol, Linkoping, Sweden,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Tholander, Bengt (författare)
- Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi,Uppsala Univ, Sweden
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- Åvall Lundqvist, Elisabeth (författare)
- Linköpings universitet,Linköping University,Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden;Linkoping Univ, Dept Clin Oncol, Linkoping, Sweden,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Högberg, Thomas (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Canc Epidemiol, Lund, Sweden
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(creator_code:org_t)
- TAYLOR & FRANCIS LTD, 2019
- 2019
- Engelska.
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Ingår i: Acta oncologica (Stockholm, Sweden). - : TAYLOR & FRANCIS LTD. - 1651-226X .- 0284-186X. ; , s. 1628-1633
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: The aim of this study is to evaluate the impact of lymphovascular space invasion (LVSI) on the risk of lymph node metastases and survival in endometrioid endometrial adenocarcinoma. Material and methods: As regard the study design, this is a cohort study based on prospectively recorded data. Patients with endometrioid endometrial adenocarcinoma registered in the Swedish Quality Registry for Gynecologic Cancer 2010-2017 with FIGO stages I-III and verified nodal status were identified (n = 1587). LVSI together with established risk factors, namely DNA ploidy, FIGO grade, myometrial invasion and age, were included in multivariable regression analyses with lymph node metastases as the dependent variable. Associations between the risk factors and overall and relative survival were included in multivariable models. Estimates of risk ratios (RR), hazard ratios (HR), excess mortality rate ratios (EMR), and 95% confidence intervals (95% CI) were calculated. Results: The presence of LVSI presented the strongest association with lymph node metastases (RR = 5.46, CI 3.69-8.07, p < .001) followed by deep myometrial invasion (RR = 1.64, CI 1.13-2.37). In the multivariable survival analyses, LVSI (EMR = 7.69, CI 2.03-29.10,) and non-diploidy (EMR = 3.23, CI 1.25-8.41) were associated with decreased relative survival. In sub-analyses including only patients with complete para-aortic and pelvic lymphadenectomy and negative lymph nodes (n = 404), only LVSI (HR = 2.50, CI 1.05-5.98) was associated with a worsened overall survival. Conclusion: This large nationwide study identified LVSI as the strongest independent risk factor for lymph node metastases and decreased survival in patients with endometrioid adenocarcinomas. Moreover, decreased overall survival was also seen in patients with LVSI-positive tumors and negative lymph nodes, indicating that hematogenous dissemination might also be important.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Stålberg, Karin
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Bjurberg, Maria
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Borgfeldt, Chris ...
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Carlson, Joseph
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Dahm-Kähler, Per ...
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Flöter-Rådestad, ...
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visa fler...
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Hellman, Kristin ...
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Hjerpe, Elisabet
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Holmberg, Erik
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Kjölhede, Preben
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Marcickiewicz, J ...
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Rosenberg, Per
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Tholander, Bengt
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Åvall Lundqvist, ...
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Högberg, Thomas
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
- Artiklar i publikationen
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Acta oncologica ...
- Av lärosätet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet
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Linköpings universitet