Sökning: onr:"swepub:oai:lup.lub.lu.se:bacbeb2f-b8f4-4ca0-bafd-94a9dc3f73e5" >
Genetic Variants As...
Genetic Variants Associated with Neuropeptide Y Autoantibody Levels in Newly Diagnosed Individuals with Type 1 Diabetes
-
- Mansachs, Sara Juul (författare)
- University of Copenhagen,Gentofte Hospital
-
- Villumsen, Sofie Olund (författare)
- Steno Diabetes Center Copenhagen
-
- Johannesen, Jesper (författare)
- Gentofte Hospital,Steno Diabetes Center Copenhagen
-
visa fler...
-
- Lind, Alexander (författare)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Medicon Valley Alliance (MVA)
-
- Kaur, Simranjeet (författare)
- Steno Diabetes Center Copenhagen
-
- Pociot, Flemming (författare)
- Steno Diabetes Center Copenhagen,Gentofte Hospital,University of Copenhagen
-
visa färre...
-
(creator_code:org_t)
- 2022-05-12
- 2022
- Engelska.
-
Ingår i: Genes. - : MDPI AG. - 2073-4425. ; 13:5
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- (1) Autoantibodies to the leucine variant of neuropeptide Y (NPY-LA) have been found in individuals with type 1 diabetes (T1D). We investigated the association between the levels of NPY-LA and single nucleotide polymorphisms (SNP) to better understand the genetic regulatory mechanisms of autoimmunity in T1D and the functional impacts of increased NPY-LA levels. (2) NPY-LA measurements from serum and SNP genotyping were done on 560 newly diagnosed individuals with T1D. SNP imputation with the 1000 Genomes reference panel was followed by an association analysis between the SNPs and measured NPY-LA levels. Additionally, functional enrichment and pathway analyses were done. (3) Three loci (DGKH, DCAF5, and LINC02261) were associated with NPY-LA levels (p-value < 1.5 × 10−6), which indicates an association with neurologic and vascular disorders. SNPs associated with variations in expression levels were found in six genes (including DCAF5). The pathway analysis showed that NPY-LA was associated with changes in gene tran-scription, protein modification, immunological functions, and the MAPK pathway. (4) Conclu-sively, we found NPY-LA to be significantly associated with three loci (DGKH, DCAF5, and LINC02261), and based on our findings we hypothesize that the presence of NPY-LA is associated with the regulation of the immune system and possibly neurologic and vascular disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- autoimmunity
- genetic regulatory mechanisms
- GWAS
- minor autoantigen
- NPY-L autoantibodies
- type 1 diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
-
Genes
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas