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Increasing number o...
Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles
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- van den Berg, Niels (författare)
- Leiden University Medical Centre,Lund University
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- Rodríguez-Girondo, Mar (författare)
- Leiden University Medical Centre
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- van Dijk, Ingrid Kirsten (författare)
- Lund University,Lunds universitet,Centrum för ekonomisk demografi,Ekonomihögskolan,Ekonomisk-historiska institutionen,Centre for Economic Demography,Lund University School of Economics and Management, LUSEM,Department of Economic History,Lund University School of Economics and Management, LUSEM
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- Slagboom, P. Eline (författare)
- Leiden University Medical Centre,Max Planck Institute for Biology of Ageing
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- Beekman, Marian (författare)
- Leiden University Medical Centre
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Nature Communications. - 2041-1723. ; 14
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-generational data from two databases, LLS (Netherlands), and SEDD (Sweden). We study healthspan in 2143 families containing index persons with 26 follow-up years and two ancestral generations, comprising 17,539 persons. Our results provide strong evidence that an increasing number of long-lived ancestors associates with up to a decade of healthspan extension. Further evidence indicates that members of long-lived families have a delayed onset of medication use, multimorbidity and, in mid-life, healthier metabolomic profiles than their partners. We conclude that both lifespan and healthspan are quantitatively linked to ancestral longevity, making family data invaluable to identify protective mechanisms of multimorbidity.
Ämnesord
- SAMHÄLLSVETENSKAP -- Ekonomi och näringsliv -- Ekonomisk historia (hsv//swe)
- SOCIAL SCIENCES -- Economics and Business -- Economic History (hsv//eng)
Nyckelord
- Aging
- Healty lifespan
- Family shared survival
- Family shared health
- Historical demography
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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