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Sources of diacylgl...
Sources of diacylglycerols for phospholipid synthesis in rat liver
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- Sundler, R (författare)
- Lund University,Lunds universitet,Kansli för experimentell medicinsk vetenskap,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department Office of Experimental Medical Science,Department of Experimental Medical Science,Faculty of Medicine
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Akesson, B (författare)
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- Nilsson, A (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Gastro,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 1974
- 1974
- Engelska 7 s.
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Ingår i: Biochimica et Biophysica Acta. - : Elsevier BV. - 0006-3002. ; 337:2, s. 54-248
- Relaterad länk:
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http://dx.doi.org/10...
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Abstract
Ämnesord
Stäng
- The biosynthesis of molecular species of phosphatidylethanolamine and phosphatidylcholine in isolated rat liver parenchymal cells was studied with [32P]phosphate and [3H]glycerol as precursors. Addition to the cells of albumin-bound oleic or linoleic acid resulted in the synthesis of high proportions of dioleoyl- or dilinoleoyl-phospholipids, especially from labeled glycerol. The fact that these species contained a lower proportion of 32P than of 3H indicated that other diacylglycerols than those newly synthesized via phosphatidic acids took part in phospholipid synthesis. The composition of such diacylglycerols could be calculated and was found (a) to be essentially unaffected by the presence of oleic or linoleic acid during incubation, and (b) to be very similar to the mass composition of diacylglycerol units in the phosphatidyl-cholines. This suggests that they had been formed from the phosphatidylcholines, probably by the reversal of the cholinephosphotransferase (EC 2.7.8.2) reaction. These diacylglycerols contributed about 26 and 13 % of the total diacylglycerols incorporated into phosphatidylethanolamines and phosphatidylcholines, respectively.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- Animals
- Choline
- Chromatography, Thin Layer
- Diglycerides/metabolism
- Fatty Acids/analysis
- Fatty Acids, Unsaturated/analysis
- Glycerides/metabolism
- Glycerol/metabolism
- Linoleic Acids/pharmacology
- Liver/cytology
- Male
- Oleic Acids/pharmacology
- Phosphatidic Acids/metabolism
- Phosphatidylcholines/biosynthesis
- Phosphatidylethanolamines/biosynthesis
- Phospholipids/biosynthesis
- Phosphotransferases/metabolism
- Rats
- Tritium
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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