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Crohn's disease ass...
Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes
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Ghandil, P (författare)
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Chelala, C (författare)
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Dubois-Laforgue, D (författare)
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Senee, V (författare)
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Caillat-Zucman, S (författare)
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- Kockum, I (författare)
- Karolinska Institutet
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- Luthman, Holger (författare)
- Lund University,Lunds universitet,Genetik,Forskargrupper vid Lunds universitet,Genetics,Lund University Research Groups
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Nerup, J (författare)
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Pociot, F (författare)
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Timsit, J (författare)
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Julier, C (författare)
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- Engelska.
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Ingår i: Molecular Genetics and Metabolism. - : Elsevier BV. - 1096-7192. ; 86:3, s. 379-383
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Three variants in the caspase recruitment domain 15/nucleotide-binding oligomerization domain 2 (CARD15/NOD2) gene have been shown to be associated with Crohn's disease (CD). There is a strong support for shared genetic determinants between various autoimmune and inflammatory diseases. In particular, linkage of type 1 diabetes (T1D) and other autoimmune and inflammatory diseases has been reported on chromosome 16, encompassing the region containing the CARD15 gene. We therefore considered this gene as a good candidate for the T1D locus mapped to this region, and we tested the three CARD15 variants in the susceptibility to T I D in two independent settings: family based association analysis in Scandinavian multiplex families that we previously showed to be linked to this region, and case/control association study in a large cohort of French diabetic patients. We found no evidence for association of these variants with T1D overall, nor in subgroups of patients with or without the major risk genotypes at HLA-DRB1, at insulin (INS), or positive or negative for autoantibodies specific to other autoimmune diseases. Our results do not support a role for CD-associated CARD15 variants in the susceptibility to T1D, and suggest that another gene is responsible for the shared susceptibility between autoimmune and inflammatory diseases mapping to this region.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Crohn's disease
- genetic variant
- association
- type 1 diabetes
- genetics
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ghandil, P
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Chelala, C
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Dubois-Laforgue, ...
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Senee, V
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Caillat-Zucman, ...
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Kockum, I
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visa fler...
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Luthman, Holger
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Nerup, J
-
Pociot, F
-
Timsit, J
-
Julier, C
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Medicinska och f ...
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och Medicinsk geneti ...
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Molecular Geneti ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet