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Sökning: onr:"swepub:oai:lup.lub.lu.se:bdcc5b26-4bf2-403e-b2f5-751146d8e866" > Crohn's disease ass...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003474naa a2200493 4500
001oai:lup.lub.lu.se:bdcc5b26-4bf2-403e-b2f5-751146d8e866
003SwePub
008160401s2005 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1947146
0247 a https://lup.lub.lu.se/record/2129182 URI
0247 a https://doi.org/10.1016/j.ymgme.2005.07.0292 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19471462 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ghandil, P4 aut
2451 0a Crohn's disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes
264 1b Elsevier BV,c 2005
520 a Three variants in the caspase recruitment domain 15/nucleotide-binding oligomerization domain 2 (CARD15/NOD2) gene have been shown to be associated with Crohn's disease (CD). There is a strong support for shared genetic determinants between various autoimmune and inflammatory diseases. In particular, linkage of type 1 diabetes (T1D) and other autoimmune and inflammatory diseases has been reported on chromosome 16, encompassing the region containing the CARD15 gene. We therefore considered this gene as a good candidate for the T1D locus mapped to this region, and we tested the three CARD15 variants in the susceptibility to T I D in two independent settings: family based association analysis in Scandinavian multiplex families that we previously showed to be linked to this region, and case/control association study in a large cohort of French diabetic patients. We found no evidence for association of these variants with T1D overall, nor in subgroups of patients with or without the major risk genotypes at HLA-DRB1, at insulin (INS), or positive or negative for autoantibodies specific to other autoimmune diseases. Our results do not support a role for CD-associated CARD15 variants in the susceptibility to T1D, and suggest that another gene is responsible for the shared susceptibility between autoimmune and inflammatory diseases mapping to this region.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Crohn's disease
653 a genetic variant
653 a association
653 a type 1 diabetes
653 a genetics
7001 a Chelala, C4 aut
7001 a Dubois-Laforgue, D4 aut
7001 a Senee, V4 aut
7001 a Caillat-Zucman, S4 aut
7001 a Kockum, Iu Karolinska Institutet4 aut
7001 a Luthman, Holgeru Lund University,Lunds universitet,Genetik,Forskargrupper vid Lunds universitet,Genetics,Lund University Research Groups4 aut0 (Swepub:lu)endo-hlu
7001 a Nerup, J4 aut
7001 a Pociot, F4 aut
7001 a Timsit, J4 aut
7001 a Julier, C4 aut
7102 a Karolinska Institutetb Genetik4 org
7730 t Molecular Genetics and Metabolismd : Elsevier BVg 86:3, s. 379-383q 86:3<379-383x 1096-7192
8564 u http://dx.doi.org/10.1016/j.ymgme.2005.07.029y FULLTEXT
8564 8u https://lup.lub.lu.se/record/212918
8564 8u https://doi.org/10.1016/j.ymgme.2005.07.029
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1947146

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