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Haploidentical Stem...
Haploidentical Stem Cell Transplantation for Refractory/Relapsed Neuroblastoma
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- Illhardt, Toni (författare)
- University Hospital of Tubingen
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- Toporski, Jacek (författare)
- Skåne University Hospital
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- Feuchtinger, Tobias (författare)
- German Center for Lung Research (DZL)
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- Turkiewicz, Dominik (författare)
- Skåne University Hospital
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- Teltschik, Heiko Manuel (författare)
- University Hospital of Tubingen
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- Ebinger, Martin (författare)
- University Hospital of Tubingen
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- Schwarze, Carl Philipp (författare)
- University Hospital of Tubingen
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- Holzer, Ursula (författare)
- University Hospital of Tubingen
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- Lode, Holger N. (författare)
- University Hospital Greifswald
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- Albert, Michael H. (författare)
- German Center for Lung Research (DZL)
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- Gruhn, Bernd (författare)
- Universitätsklinikum Jena
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- Urban, Christian (författare)
- Medical University of Graz
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- Dykes, Josefina H. (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Region Skåne
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- Teuffel, Oliver (författare)
- University of Tübingen
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- Schumm, Michael (författare)
- University Hospital of Tubingen
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- Handgretinger, Rupert (författare)
- University Hospital of Tubingen
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- Lang, Peter (författare)
- University Hospital of Tubingen
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Biology of Blood and Marrow Transplantation. - : Elsevier BV. - 1083-8791. ; 24:5, s. 1005-1012
- Relaterad länk:
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http://dx.doi.org/10...
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http://www.bbmt.org/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Pediatric patients with refractory or relapsed metastatic neuroblastoma (NBL) have a poor prognosis despite autologous stem cell transplantation (SCT). Allogeneic SCT from a haploidentical donor has a remarkable alloreactive effect in patients with leukemia; thus, we evaluated this approach in children with very high-risk NBL. We analyzed data from 2 prospective phase I/II trials. A total of 26 patients with refractory (n = 5), metastatic relapsed (n = 20), or locally relapsed MYCN-positive (n = 1) NBL received a median of 17 × 106/kg T/B cell-depleted CD34+ stem cells with 68 × 103/kg residual T cells and 107 × 106/kg natural killer cells. The conditioning regimen comprised melphalan, fludarabine, thiotepa, OKT3, and a short course of mycophenolate mofetil post-transplantation. Engraftment occurred in 96% of the patients. Event-free survival and overall survival at 5 years were 19% and 23%, respectively. No transplantation-related mortality was observed, and the single death was due to progression/subsequent relapse. The median duration of follow-up was 8.1 years. Patients in complete remission before SCT had a significantly better prognosis than those with residual tumor load (P < .01). All patients with progressive disease before SCT relapsed within 1 year. Grade II and grade III acute graft-versus-host disease (GVHD) occurred in 31% and 12% of the patients, respectively. Chronic limited and extensive GVHD occurred in 28% and 10%, respectively. Our data indicate that haploidentical SCT is a feasible treatment option that can induce long-term remission in some patients with NBL with tolerable side effects, and may enable the development of further post-transplantation therapeutic strategies based on the donor-derived immune system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Allogeneic stem cell transplantation
- Graft-versus-host disease
- Graft-versus-tumor effect
- Haploidentical
- Neuroblastoma
- Transplantation-related mortality
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Illhardt, Toni
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Toporski, Jacek
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Feuchtinger, Tob ...
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Turkiewicz, Domi ...
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Teltschik, Heiko ...
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Ebinger, Martin
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visa fler...
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Schwarze, Carl P ...
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Holzer, Ursula
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Lode, Holger N.
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Albert, Michael ...
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Gruhn, Bernd
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Urban, Christian
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Dykes, Josefina ...
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Teuffel, Oliver
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Schumm, Michael
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Handgretinger, R ...
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Lang, Peter
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Biology of Blood ...
- Av lärosätet
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Lunds universitet