Sökning: onr:"swepub:oai:lup.lub.lu.se:c00818be-8f78-4971-9802-918c8f78adff" > Lymphocyte subpopul...
Fältnamn | Indikatorer | Metadata |
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000 | 03672naa a2200397 4500 | |
001 | oai:lup.lub.lu.se:c00818be-8f78-4971-9802-918c8f78adff | |
003 | SwePub | |
008 | 160401s1988 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/11040942 URI |
024 | 7 | a https://doi.org/10.3109/088800188090312642 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Dohlsten, M4 aut |
245 | 1 0 | a Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia |
264 | c 2009-07-09 | |
264 | 1 | b Informa UK Limited,c 1988 |
520 | a The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of bone marrow failure also exhibited the lowest T4/T8 ratio. No spontaneous IFN production was detected in any of the patients. There was no clinical benefit or reversal of the immune abnormalities during and following treatment with cimetidine and cyclosporine A in two patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
700 | 1 | a Hedlund, G4 aut |
700 | 1 | a Békássy, Albertu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)al4445be |
700 | 1 | a Lindén, Olau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-oli |
700 | 1 | a Garwicz, Stanislawu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)st6750ga |
700 | 1 | a Wiebe, Thomasu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pedi-twi |
700 | 1 | a Sjögren, H O4 aut |
700 | 1 | a Carlsson, R4 aut |
710 | 2 | a Pediatrik, Lundb Sektion V4 org |
773 | 0 | t Pediatric Hematology & Oncologyd : Informa UK Limitedg 5:2, s. 143-151q 5:2<143-151x 1521-0669x 0888-0018 |
856 | 4 | u http://dx.doi.org/10.3109/08880018809031264y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1104094 |
856 | 4 8 | u https://doi.org/10.3109/08880018809031264 |
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