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Comparison of Effec...
Comparison of Effect of Ischemic Postconditioning on Cardiovascular Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention With Versus Without Thrombectomy
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- Madsen, Jasmine Melissa (författare)
- Copenhagen University Hospital
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- Glinge, Charlotte (författare)
- Copenhagen University Hospital
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- Jabbari, Reza (författare)
- Copenhagen University Hospital
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- Nepper-Christensen, Lars (författare)
- Copenhagen University Hospital
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- Høfsten, Dan Eik (författare)
- Copenhagen University Hospital
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- Tilsted, Hans Henrik (författare)
- Copenhagen University Hospital
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- Holmvang, Lene (författare)
- Copenhagen University Hospital
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- Pedersen, Frants (författare)
- Copenhagen University Hospital
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- Joshi, Francis Richard (författare)
- Copenhagen University Hospital
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- Sørensen, Rikke (författare)
- Copenhagen University Hospital
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- Bang, Lia Evi (författare)
- Copenhagen University Hospital
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- Bøtker, Hans Erik (författare)
- Aarhus University Hospital
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- Terkelsen, Christian Juhl (författare)
- Aarhus University Hospital
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- Mæng, Michael (författare)
- Aarhus University Hospital
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- Jensen, Lisette Okkels (författare)
- Odense University Hospital
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- Aarøe, Jens (författare)
- Aalborg University Hospital
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- Kelbæk, Henning (författare)
- Zealand University Hospital
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- Torp-Pedersen, Christian (författare)
- Hillerod Hospital,Aalborg University Hospital,University of Copenhagen
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- Køber, Lars (författare)
- Copenhagen University Hospital
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- Lønborg, Jacob Thomsen (författare)
- Copenhagen University Hospital
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- Engstrøm, Thomas (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: American Journal of Cardiology. - : Elsevier BV. - 0002-9149. ; 166, s. 18-24
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Abstract
Ämnesord
Stäng
- In patients with ST-segment elevation myocardial infarction (STEMI), ischemic postconditioning (iPOST) have shown ambiguous results in minimizing reperfusion injury. Previous findings show beneficial effects of iPOST in patients with STEMI treated without thrombectomy. However, it remains unknown whether the cardioprotective effect of iPOST in these patients persist on long term. In the current study, all patients were identified through the DANAMI-3-iPOST database. Patients were randomized to conventional primary percutaneous coronary intervention (PCI) or iPOST in addition to PCI. Cumulative incidence rates were calculated, and multivariable analyses stratified according to thrombectomy use were performed. The primary end point was a combination of cardiovascular mortality and hospitalization for heart failure. From 2011 to 2014, 1,234 patients with STEMI were included with a median follow-up of 4.8 years. In patients treated without thrombectomy (n = 520), the primary end point occurred in 15% (48/326) in the iPOST group and in 22% (42/194) in the conventional group (unadjusted hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.41 to 0.94, p = 0.023). In adjusted Cox analysis, iPOST remained associated with reduced long-term risk of cardiovascular mortality (HR 0.53, 95% CI 0.29 to 0.97, p = 0.039). In patients treated with thrombectomy (n = 714), there was no significant difference between iPOST (17%, 49/291) and conventional treatment (17%, 72/423) on the primary end point (unadjusted HR 1.01, 95% CI 0.70 to 1.45, p = 0.95). During a follow-up of nearly 5 years, iPOST reduced long-term occurrence of cardiovascular mortality and hospitalization for heart failure in patients with STEMI treated with PCI but without thrombectomy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Madsen, Jasmine ...
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Glinge, Charlott ...
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Jabbari, Reza
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Nepper-Christens ...
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Høfsten, Dan Eik
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Tilsted, Hans He ...
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Holmvang, Lene
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Pedersen, Frants
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Joshi, Francis R ...
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Sørensen, Rikke
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Bang, Lia Evi
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Bøtker, Hans Eri ...
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Terkelsen, Chris ...
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Mæng, Michael
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Jensen, Lisette ...
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Aarøe, Jens
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Kelbæk, Henning
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Torp-Pedersen, C ...
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Køber, Lars
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Lønborg, Jacob T ...
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Engstrøm, Thomas
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