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High Diversity of G...
High Diversity of Giardia duodenalis Assemblages and Sub-Assemblages in Asymptomatic School Children in Ibadan, Nigeria
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- Tijani, Muyideen K. (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Malaria och Babesia,Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Malaria and Babesia,Lund University Research Groups,University of Ibadan
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- Köster, Pamela C. (författare)
- Spanish National Centre for Microbiology
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- Guadano-Procesi, Isabel (författare)
- University of Rome Tor Vergata
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- George, Imo S. (författare)
- University of Ibadan
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- Abodunrin, Elizabeth (författare)
- University of Ibadan
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- Adeola, Adedamola (författare)
- University of Ibadan
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- Dashti, Alejandro (författare)
- Spanish National Centre for Microbiology
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- Bailo, Begoña (författare)
- Spanish National Centre for Microbiology
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- González-Barrio, David (författare)
- Spanish National Centre for Microbiology
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- Carmena, David (författare)
- Spanish National Centre for Microbiology
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(creator_code:org_t)
- 2023-02-28
- 2023
- Engelska.
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Ingår i: Tropical Medicine and Infectious Disease. - : MDPI AG. - 2414-6366. ; 8:3
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Giardia duodenalis is a significant contributor to the burden of diarrheal disease in sub-Saharan Africa. This study assesses the occurrence and molecular diversity of G. duodenalis and other intestinal parasites in apparently healthy children (n = 311) in Ibadan, Nigeria. Microscopy was used as a screening method and PCR and Sanger sequencing as confirmatory and genotyping methods, respectively. Haplotype analyses were performed to examine associations between genetic variants and epidemiological variables. At microscopy examination, G. duodenalis was the most prevalent parasite found (29.3%, 91/311; 95% CI: 24.3–34.7), followed by Entamoeba spp. (18.7%, 58/311; 14.5–23.4), Ascaris lumbricoides (1.3%, 4/311; 0.4–3.3), and Taenia sp. (0.3%, 1/311; 0.01–1.8). qPCR confirmed the presence of G. duodenalis in 76.9% (70/91) of the microscopy-positive samples. Of them, 65.9% (60/91) were successfully genotyped. Assemblage B (68.3%, 41/60) was more prevalent than assemblage A (28.3%, 17/60). Mixed A + B infections were identified in two samples (3.3%, 2/60). These facts, together with the absence of animal-adapted assemblages, suggest that human transmission of giardiasis was primarily anthroponotic. Efforts to control G. duodenalis (and other fecal-orally transmitted pathogens) should focus on providing safe drinking water and improving sanitation and personal hygiene practices.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Africa
- diarrhea
- epidemiology
- giardiasis
- intestinal parasites
- transmission
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tijani, Muyideen ...
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Köster, Pamela C ...
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Guadano-Procesi, ...
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George, Imo S.
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Abodunrin, Eliza ...
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Adeola, Adedamol ...
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visa fler...
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Dashti, Alejandr ...
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Bailo, Begoña
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González-Barrio, ...
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Carmena, David
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Tropical Medicin ...
- Av lärosätet
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Lunds universitet