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Randomized Controll...
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation : Outcome at 2 Years
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- Cizmeci, Mehmet N (författare)
- University of Toronto
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- Groenendaal, Floris (författare)
- Erasmus University Medical Center
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- Liem, Kian D (författare)
- Radboud University Medical Center
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- van Haastert, Ingrid C (författare)
- Erasmus University Medical Center
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- Benavente-Fernández, Isabel (författare)
- Puerta del Mar University Hospital
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- van Straaten, Henrica L M (författare)
- Isala Women and Children's Hospital
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- Steggerda, Sylke (författare)
- Leiden University Medical Centre
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- Smit, Bert J (författare)
- Erasmus University Medical Center
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- Whitelaw, Andrew (författare)
- University of Bristol
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- Woerdeman, Peter (författare)
- University Medical Center Utrecht
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- Heep, Axel (författare)
- University of Bristol
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- de Vries, Linda S (författare)
- Erasmus University Medical Center
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- Ley, David (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups
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- Fellman, Vineta (creator_code:cre_t)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
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- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Journal of Pediatrics. - : Elsevier BV. - 1097-6833 .- 0022-3476. ; 226, s. 3-35
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To compare the effect of intervention at low vs high threshold of ventriculomegaly in preterm infants with posthemorrhagic ventricular dilatation on death or severe neurodevelopmental disability.STUDY DESIGN: This multicenter randomized controlled trial reviewed lumbar punctures initiated after either a low threshold (ventricular index of >p97 and anterior horn width of >6 mm) or high threshold (ventricular index of >p97 + 4 mm and anterior horn width of >10 mm). The composite adverse outcome was defined as death or cerebral palsy or Bayley composite cognitive/motor scores <-2 SDs at 24 months corrected age.RESULTS: Outcomes were assessed in 113 of 126 infants. The composite adverse outcome was seen in 20 of 58 infants (35%) in the low threshold group and 28 of 55 (51%) in the high threshold (P = .07). The low threshold intervention was associated with a decreased risk of an adverse outcome after correcting for gestational age, severity of intraventricular hemorrhage, and cerebellar hemorrhage (aOR, 0.24; 95% CI, 0.07-0.87; P = .03). Infants with a favorable outcome had a smaller fronto-occipital horn ratio (crude mean difference, -0.06; 95% CI, -0.09 to -0.03; P < .001) at term-equivalent age. Infants in the low threshold group with a ventriculoperitoneal shunt, had cognitive and motor scores similar to those without (P = .3 for both), whereas in the high threshold group those with a ventriculoperitoneal shunt had significantly lower scores than those without a ventriculoperitoneal shunt (P = .01 and P = .004, respectively).CONCLUSIONS: In a post hoc analysis, earlier intervention was associated with a lower odds of death or severe neurodevelopmental disability in preterm infants with progressive posthemorrhagic ventricular dilatation.TRIAL REGISTRATION: ISRCTN43171322.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Cerebral Hemorrhage/complications
- Cerebral Ventricles/pathology
- Child, Preschool
- Cohort Studies
- Dilatation, Pathologic
- Female
- Humans
- Infant
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases/psychology
- Male
- Neurodevelopmental Disorders/diagnosis
- Spinal Puncture
- Time-to-Treatment
- Ventriculoperitoneal Shunt
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Cizmeci, Mehmet ...
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Groenendaal, Flo ...
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Liem, Kian D
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van Haastert, In ...
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Benavente-Fernán ...
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van Straaten, He ...
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visa fler...
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Steggerda, Sylke
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Smit, Bert J
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Whitelaw, Andrew
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Woerdeman, Peter
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Heep, Axel
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de Vries, Linda ...
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Ley, David
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Fellman, Vineta
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
- Artiklar i publikationen
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Journal of Pedia ...
- Av lärosätet
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Lunds universitet